在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PDE11A Antibody, FITC conjugated

  • 中文名稱:
    PDE11A兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA875726LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PDE11A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PDE11A
  • 別名:
    5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody; cAMP and cGMP phosphodiesterase 11A antibody; cGMP phosphodiesterase 11A antibody; Cyclic nucleotide phosphodiesterase 11A antibody; Dual 3'' antibody; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody; pde11 antibody; PDE11_HUMAN antibody; pde11a antibody; PDE11A1 antibody; pde11a2 antibody; Phosphodiesterase 11A antibody; PPNAD2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • 基因功能參考文獻:
    1. One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke. PMID: 26820475
    2. Testicular germ cell tumors had 55 PDE11A variants: 20 missense (10 new, 9 in transcript variant 4, 1 in transcript variant 3), 4 splice-site, 2 nonsense, 7 synonymous, and 22 intronic. p.F258Y, p.G291R, p.V820M, p.R545X, and p.K568R were only in cases. PMID: 26459559
    3. PDE11A genetic variants may increase predisposition to ACTH-independent macronodular adrenal hyperplasia. PMID: 22996146
    4. found in single nerve trunks in the clitoral stroma PMID: 21697861
    5. Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostate cancer PMID: 20881257
    6. We demonstrate, in a large cohort of Carney Complex patients, a high frequency of PDE11A variants, suggesting that PDE11A is a genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation. PMID: 21047926
    7. PDE11A SNP assocaited with allergic asthma. PMID: 20920776
    8. we detected protein corresponding to PDE11A4, in human prostate, pituitary, heart and liver PMID: 15800651
    9. PDE11A genetic defects may be associated with adrenal pathology in a wider than previously suspected and is associated with adrenal hyperplasia and adenomas. PMID: 17178847
    10. Variants in PDE11A are not associated with citalopram response in patient with depression. PMID: 18043711
    11. N-terminal modifications strongly affect cGMP regulation of hPDE11A4 PMID: 18312413
    12. PDE11A is expressed widely in adrenal cortex. Its expression appears to be increased in PPNAD but varies widely among other adrenocortical tumors. PMID: 18491255
    13. PDE11A sequence defects predispose to a variety of lesions (beyond micronodular adrenocortical hyperplasia). PMID: 18559625
    14. PDE11A, is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
    15. PDE11A-inactivating sequence variants may modify the risk of familial and bilateral testicular germ cell tumors. PMID: 19549888
    16. Immunohistochemistry revealed PDE11A expression higher in somatotropinomas than in normal somatotrophs, without significant difference between tumors with or without PDE11A variants. PMID: 19671705

    顯示更多

    收起更多

  • 相關疾病:
    Primary pigmented nodular adrenocortical disease 2 (PPNAD2)
  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Cyclic nucleotide phosphodiesterase family
  • 組織特異性:
    Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is ex
  • 數據庫鏈接:

    HGNC: 8773

    OMIM: 604961

    KEGG: hsa:50940

    STRING: 9606.ENSP00000286063

    UniGene: Hs.570273



主站蜘蛛池模板: 在线观看片免费人成视频无码| 亚洲色成人网站www永久蜜芽| 天天摸天天摸天天天天看| 国产激情电影综合在线看| 又色又爽又黄的视频网站| 麻花豆传媒剧国产免费mv入口| 人妻丰满熟妇av无码片| 天天爽天天爽天天片a| 国产啪精品视频网站| 国产在线aaa片一区二区99| 成人无码免费视频在线播| 精品多人p群无码| 麻花传媒在线观看免费| 美女张开腿让人桶| 久久精品aⅴ无码中文字字幕不卡| 97人摸人人澡人人人超碰| 精品久久久久中文字幕一区| 吃奶呻吟打开双腿做受在线视频 | 成年片色大黄全免费网站久久| 男人边吃奶边揉好爽免费视频 | 中文精品无码中文字幕无码专区| 亚洲日韩小电影在线观看| 国产交换配偶在线视频| 伊伊综合在线视频无码| 亚洲欧洲无卡二区视頻| 无码人妻丝袜视频在线播免费| 伊人久久大香线蕉亚洲五月天| 国产成a人亚洲精品无码樱花 | 草裙社区精品视频三区免费看 | 亚洲成h人av无码动漫无遮挡| 日韩国产亚洲一区二区三区| 日本边添边摸边做边爱| 人人妻人人澡人人爽国产一区| a狠狠久久蜜臀婷色中文网| 色欲久久久中文字幕综合网| 日韩人妻一区二区三区免费| 国产成人无码va在线观看| 亚欧日韩欧美网站在线看| 精品国产人妻一区二区三区| 欧美大屁股流白浆xxxx| 又色又爽又黄还免费毛片96下载|