在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PDE11A Antibody, HRP conjugated

PDE11A Antibody, HRP conjugated

  • 中文名稱：
    PDE11A兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA875726LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PDE11A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PDE11A
  • 別名：
    5''-cyclic-AMP and -GMP phosphodiesterase 11A antibody; cAMP and cGMP phosphodiesterase 11A antibody; cGMP phosphodiesterase 11A antibody; Cyclic nucleotide phosphodiesterase 11A antibody; Dual 3'' antibody; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A antibody; pde11 antibody; PDE11_HUMAN antibody; pde11a antibody; PDE11A1 antibody; pde11a2 antibody; Phosphodiesterase 11A antibody; PPNAD2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A protein (42-190AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
  • 基因功能參考文獻(xiàn)：
    1. One percent of the Swedish population carries a PDE11A loss-of-function mutation which is associated with elevated BP, abdominal obesity, and risk of ischemic stroke. PMID: 26820475
    2. Testicular germ cell tumors had 55 PDE11A variants: 20 missense (10 new, 9 in transcript variant 4, 1 in transcript variant 3), 4 splice-site, 2 nonsense, 7 synonymous, and 22 intronic. p.F258Y, p.G291R, p.V820M, p.R545X, and p.K568R were only in cases. PMID: 26459559
    3. PDE11A genetic variants may increase predisposition to ACTH-independent macronodular adrenal hyperplasia. PMID: 22996146
    4. found in single nerve trunks in the clitoral stroma PMID: 21697861
    5. Our data suggest that, like in the adrenal cortex and the testicular germ cells, PDE11A-inactivating genetic alterations may play a role in susceptibility to prostate cancer PMID: 20881257
    6. We demonstrate, in a large cohort of Carney Complex patients, a high frequency of PDE11A variants, suggesting that PDE11A is a genetic modifying factor for the development of testicular and adrenal tumors in patients with germline PRKAR1A mutation. PMID: 21047926
    7. PDE11A SNP assocaited with allergic asthma. PMID: 20920776
    8. we detected protein corresponding to PDE11A4, in human prostate, pituitary, heart and liver PMID: 15800651
    9. PDE11A genetic defects may be associated with adrenal pathology in a wider than previously suspected and is associated with adrenal hyperplasia and adenomas. PMID: 17178847
    10. Variants in PDE11A are not associated with citalopram response in patient with depression. PMID: 18043711
    11. N-terminal modifications strongly affect cGMP regulation of hPDE11A4 PMID: 18312413
    12. PDE11A is expressed widely in adrenal cortex. Its expression appears to be increased in PPNAD but varies widely among other adrenocortical tumors. PMID: 18491255
    13. PDE11A sequence defects predispose to a variety of lesions (beyond micronodular adrenocortical hyperplasia). PMID: 18559625
    14. PDE11A, is unlikely to play an important role in antidepressant outcome in this sample PMID: 19214142
    15. PDE11A-inactivating sequence variants may modify the risk of familial and bilateral testicular germ cell tumors. PMID: 19549888
    16. Immunohistochemistry revealed PDE11A expression higher in somatotropinomas than in normal somatotrophs, without significant difference between tumors with or without PDE11A variants. PMID: 19671705

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Primary pigmented nodular adrenocortical disease 2 (PPNAD2)
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 組織特異性：
    Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is ex
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8773

    OMIM: 604961

    KEGG: hsa:50940

    STRING: 9606.ENSP00000286063

    UniGene: Hs.570273



主站蜘蛛池模板： 欧美日韩亚洲国产综合乱| 天码人妻一区二区三区| 国精品99久9在线 | 免费| 国产欧美日韩精品专区| 亚洲精品1卡2卡三卡23卡| 夜夜欢天天干| 美女脱了内裤张开腿让男人桶网站| 搡8o老女人老妇人老熟| 337p日本欧洲亚洲大胆色噜噜| 上司揉捏人妻丰满双乳电影| 人妻影音先锋啪啪av资源| 亚洲中国最大av网站| 欧美熟妇色ⅹxxx欧美妇| 在厨房被c到高潮a毛片奶水| 精品丝袜人妻久久久久久| 国产九九99久久99大香伊| 日韩欧美亚洲综合久久影院ds| 精品免费国产一区二区三区四区介绍 | 日韩卡二卡三卡四卡永久入口| 亚洲一区二区三区中文字幕在线| 人与性动交aaaabbbb| 精品国产一区二区三区四区vr| 国产精品香港三级国产av| 亚洲精品夜夜夜妓女网| 色综合欧美五月俺也去| 亚洲色无码播放| 明星性猛交ⅹxxx乱大交| 法国白嫩大屁股xxxx| 天堂网www天堂在线资源| 亚洲国产成人无码av在线播放| 性欧美丰满熟妇xxxx性| 狠狠色综合激情丁香五月| 久久青青草原国产免费播放| 国产婷婷精品av在线| 亚洲男人的天堂一区二区| 日本成本人片免费网站| 少妇饥渴xxhd麻豆xxhd骆驼| 国精产品999一区二区三区有限| 亚洲精品中文字幕乱码4区| 337p粉嫩大胆色噜噜噜| 国产精品无码一区二区在线|