在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DnaJ homolog subfamily C member 15 (DNAJC15 DNAJD1 GIG22 HSD18)

  • 中文名稱:
  • 貨號:
    CSB-YP2284HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2284HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2284HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2284HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2284HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    DJC15
  • Uniprot No.:
  • 別名:
    DnaJ homolog subfamily C member 15; Cell growth-inhibiting gene 22 protein; Methylation-controlled J protein; MCJ; DNAJC15 DNAJD1 GIG22 HSD18
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
  • 基因功能參考文獻:
    1. DNAJC15 as a new target gene responsible for ETV7-mediated Doxorubicin-resistance. PMID: 30025229
    2. Acetaminophen interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ. Study also show higher levels of MCJ in livers from patients with acetaminophen-induced liver injury. PMID: 29233977
    3. this study shows that memory CD8+ T cells lacking MCJ provide superior protection against influenza virus infection PMID: 27234056
    4. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    5. These results identify the MCJ gene as a transcriptional target of IFNgamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions PMID: 26419808
    6. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. PMID: 26040030
    7. Report functional connection between mitochondrial inner membrane protein translocation machinery-associated J-protein DnaJC15 and regulation of cell death pathways. PMID: 24603329
    8. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
    9. loss of expression of MCJ by DNA methylation is associated with drug-resistance in ovarian cancer PMID: 14729589
    10. evidence of MCJ hypermethylation in intracranial primitive neuroectodermal tumours (PNETs) (medulloblastomas, supratentorial PNETs & ependymomas); data indicate epigenetic inactivation of MCJ may play a role in development of pediatric brain tumours PMID: 16049974
    11. MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response. PMID: 17283040
    12. Following transient expression of MDR-1 and MCJ, changes in the sensitivity of Sk-Ov-3 cells to paclitaxel were detected whereas expression of Src, Bcl-2 and Bcl-X(L) decreased the sensitivity of Sk-Ov-3 cells to carboplatin. PMID: 18324624

    顯示更多

    收起更多

  • 相關疾病:
    Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed at highest levels in heart, followed by liver and kidney.
  • 數據庫鏈接:

    HGNC: 20325

    OMIM: 615339

    KEGG: hsa:29103

    STRING: 9606.ENSP00000368523

    UniGene: Hs.438830



主站蜘蛛池模板: 国产无遮挡又黄又爽动态图| 高清欧美性猛交xxxx黑人猛交| 忍不住的亲子中文字幕| 98国产精品综合一区二区三区| 乱人伦人妻中文字幕无码| 欧洲熟妇色 欧美| 国产成av人片在线观看天堂无码| 免费永久看黄神器无码软件| 亚洲精品国产自在现线最新| 亚洲中文字幕无码乱线| 久久婷婷香蕉热狠狠综合| 狠狠热精品免费视频| 国产日韩欧美亚洲精品中字| 99久久无码一区人妻a片潘金莲| 97熟女毛毛多熟妇人妻aⅴ| 久久久久国产精品熟女影院| 亚洲精品国产suv一区88| 日韩av无码一区二区三区| 中国农村妇女真实bbwbbwbbw| 国产 日韩 中文字幕 制服| 免费无码av一区二区三区| 蜜臀av在线播放| 亚洲午夜私人影院在线观看| 日韩国产精品人妻无码久久久| 好硬好湿好爽再深一点动态图视频| 精品亚洲国产成人av| 荫蒂添的好舒服视频囗交| 夫前人妻被灌醉侵犯在线| 亚洲精品国产一区二区图片| 欧美浓毛大泬视频| 伊人色综合久久天天五月婷| 国产精品人妻系列21p| 久久精品国产久精国产爱| 性无码一区二区三区在线观看| 先锋影音最新色资源站| 久久亚洲精品ab无码播放| 国语对白嫖老妇胖老太| 亚洲码欧美码一区二区三区| 欧洲美熟女乱又伦av影片| 国产成人mv视频在线观看| 国产成人精品s8视频|