在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DnaJ homolog subfamily C member 15 (DNAJC15 DNAJD1 GIG22 HSD18)

  • 中文名稱:
  • 貨號:
    CSB-YP2284HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2284HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2284HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2284HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2284HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    DJC15
  • Uniprot No.:
  • 別名:
    DnaJ homolog subfamily C member 15; Cell growth-inhibiting gene 22 protein; Methylation-controlled J protein; MCJ; DNAJC15 DNAJD1 GIG22 HSD18
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
  • 基因功能參考文獻:
    1. DNAJC15 as a new target gene responsible for ETV7-mediated Doxorubicin-resistance. PMID: 30025229
    2. Acetaminophen interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ. Study also show higher levels of MCJ in livers from patients with acetaminophen-induced liver injury. PMID: 29233977
    3. this study shows that memory CD8+ T cells lacking MCJ provide superior protection against influenza virus infection PMID: 27234056
    4. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    5. These results identify the MCJ gene as a transcriptional target of IFNgamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions PMID: 26419808
    6. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. PMID: 26040030
    7. Report functional connection between mitochondrial inner membrane protein translocation machinery-associated J-protein DnaJC15 and regulation of cell death pathways. PMID: 24603329
    8. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
    9. loss of expression of MCJ by DNA methylation is associated with drug-resistance in ovarian cancer PMID: 14729589
    10. evidence of MCJ hypermethylation in intracranial primitive neuroectodermal tumours (PNETs) (medulloblastomas, supratentorial PNETs & ependymomas); data indicate epigenetic inactivation of MCJ may play a role in development of pediatric brain tumours PMID: 16049974
    11. MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response. PMID: 17283040
    12. Following transient expression of MDR-1 and MCJ, changes in the sensitivity of Sk-Ov-3 cells to paclitaxel were detected whereas expression of Src, Bcl-2 and Bcl-X(L) decreased the sensitivity of Sk-Ov-3 cells to carboplatin. PMID: 18324624

    顯示更多

    收起更多

  • 相關疾病:
    Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed at highest levels in heart, followed by liver and kidney.
  • 數據庫鏈接:

    HGNC: 20325

    OMIM: 615339

    KEGG: hsa:29103

    STRING: 9606.ENSP00000368523

    UniGene: Hs.438830



主站蜘蛛池模板: 国产精品嫩草影院免费观看 | 欧美怡红院免费全部视频| 拍真实国产伦偷精品| 亚洲爆乳无码专区| 亚洲精品乱码久久久久久不卡| 国产亚洲精品久久久美女18黄| 久久久噜噜噜久久熟女色 | 一本加勒比hezyo无码人妻| 国内精品伊人久久久久影院麻豆| 又污又爽又黄的网站| 国产精品黄页免费高清在线观看 | 中国内射xxxx6981少妇| 国色天香社区在线视频| 窝窝午夜看片| 国产福利视频一区二区| 无码人妻丰满熟妇区免费| 天堂在线www资源在线| 国产日产欧产精品网站| 国产黄a三级三级三级| 婷婷久久综合九色综合| 久久国产精品免费一区| 国产精品亚洲专区无码破解版| 亚洲欧美另类久久久精品| 欧美尺码专线欧洲b1b1| 人妻精品久久无码区| 久久久久久久久久久综合日本| 人与禽交videos欧美| 亚洲欧美日韩成人综合网| 伊人久久大香线蕉综合狠狠| 精品1卡二卡三卡四卡老狼| 精品无码久久久久久久久| 亚洲综合最新无码2020av| 很黄很黄的曰批视频| 无码专区一va亚洲v专区在线| 国产精品成人久久电影| 亚洲va在线va天堂va欧美va| 97久久人人超碰超碰窝窝| 欧洲熟妇色 欧美| 日日天日日夜日日摸| 国产精品视频免费一区二区| 国产精品无码久久av|