在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DNAJC15 Antibody

  • 中文名稱:
    DNAJC15兔多克隆抗體
  • 貨號:
    CSB-PA007022GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cell growth inhibiting gene 22 protein antibody; Cell growth-inhibiting gene 22 protein antibody; DJC15_HUMAN antibody; DnaJ (Hsp40) homolog subfamily C member 15 antibody; DNAJ domain containing antibody; DnaJ homolog subfamily C member 15 antibody; DNAJC15 antibody; DNAJD1 antibody; GIG22 antibody; HSD18 antibody; MCJ antibody; Methylation controlled J protein antibody; Methylation-controlled J protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human DNAJC15
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
  • 基因功能參考文獻:
    1. DNAJC15 as a new target gene responsible for ETV7-mediated Doxorubicin-resistance. PMID: 30025229
    2. Acetaminophen interferes with the formation of mitochondrial respiratory supercomplexes via the mitochondrial negative regulator MCJ. Study also show higher levels of MCJ in livers from patients with acetaminophen-induced liver injury. PMID: 29233977
    3. this study shows that memory CD8+ T cells lacking MCJ provide superior protection against influenza virus infection PMID: 27234056
    4. Both DnaJC15 and DnaJC19 formed two distinct subcomplexes with Magmas at the import channel. PMID: 27330077
    5. These results identify the MCJ gene as a transcriptional target of IFNgamma and provide evidence of the dynamic adaptation of normal tissues to changes in the environment as a way to adapt metabolically to new conditions PMID: 26419808
    6. Changes in the expression levels of IRS1, IRS2, RIPK2, RSPO1, and DNA JC15 genes might contribute to the development of insulin resistance and glucose intolerance in the obese boys. PMID: 26040030
    7. Report functional connection between mitochondrial inner membrane protein translocation machinery-associated J-protein DnaJC15 and regulation of cell death pathways. PMID: 24603329
    8. MCJ functions as J co-chaperone of the human TIM23 pre-protein translocase. PMID: 23263864
    9. loss of expression of MCJ by DNA methylation is associated with drug-resistance in ovarian cancer PMID: 14729589
    10. evidence of MCJ hypermethylation in intracranial primitive neuroectodermal tumours (PNETs) (medulloblastomas, supratentorial PNETs & ependymomas); data indicate epigenetic inactivation of MCJ may play a role in development of pediatric brain tumours PMID: 16049974
    11. MCJ is required in these cells to prevent c-Jun-mediated expression of ABCB1 and maintain drug response. PMID: 17283040
    12. Following transient expression of MDR-1 and MCJ, changes in the sensitivity of Sk-Ov-3 cells to paclitaxel were detected whereas expression of Src, Bcl-2 and Bcl-X(L) decreased the sensitivity of Sk-Ov-3 cells to carboplatin. PMID: 18324624

    顯示更多

    收起更多

  • 相關疾病:
    Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 組織特異性:
    Expressed at highest levels in heart, followed by liver and kidney.
  • 數據庫鏈接:

    HGNC: 20325

    OMIM: 615339

    KEGG: hsa:29103

    STRING: 9606.ENSP00000368523

    UniGene: Hs.438830



主站蜘蛛池模板: 岛国在线无码高清视频| 久久精品人妻一区二区三区 | 强开小婷嫩苞又嫩又紧韩国视频| 成人av片在线观看免费| 国产老妇伦国产熟女老妇高清| 国产亚洲精品美女久久久久| 一区二区三区波多野结衣在线观看| 国产农村黄aaaaa特黄av毛片| 亚洲综合久久一本久道| 动漫av纯肉无码av在线播放| 插鸡网站在线播放免费观看| 久久婷婷五月综合中文字幕| 中文字幕一区二区三区乱码 | 中文在线中文资源| 欧美老熟妇喷水| www国产亚洲精品久久| 热99re久久国超精品首页| 300部国产真实乱| 久久久久久国产精品无码超碰| 久久天天躁狠狠躁夜夜av浪潮| 免费观看又色又爽又湿的视频| 婷婷色婷婷开心五月四房播播 | 久久精品日日躁夜夜躁欧美| 人妻av无码系列一区二区三区 | 熟妇好大好深好满好爽| 国产xxxx视频在线| 人人妻人人澡人人爽偷拍台湾| 永久免费不卡在线观看黄网站| 人人妻人人澡人人爽欧美一区 | 欧美亚洲色欲色一欲www| 日韩av无码精品一二三区| 暖暖视频日本在线观看| 新版天堂资源中文www连接| 四虎影视在线永久免费观看| 在线看片人成视频免费无遮挡| 国产又爽又黄又不遮挡视频| 精品午夜中文字幕熟女人妻在线| 国产精品免费福利久久| 成a人片亚洲日本久久| 一二三四观看视频社区在线| 伊人久久大香线蕉综合75|