在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Diphthamide biosynthesis protein 1 (DPH1)

  • 中文名稱:
    人DPH1重組蛋白
  • 貨號:
    CSB-YP871625HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人DPH1重組蛋白
  • 貨號:
    CSB-EP871625HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人DPH1重組蛋白
  • 貨號:
    CSB-EP871625HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人DPH1重組蛋白
  • 貨號:
    CSB-BP871625HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人DPH1重組蛋白
  • 貨號:
    CSB-MP871625HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Candidate tumor suppressor in ovarian cancer 1; Diphthamide biosynthesis protein 1; Diphthamide biosynthesis protein 2 homolog like 1; Diphthamide biosynthesis protein 2 homolog-like 1; Diphthamide biosynthesis protein 2 like; Diphthamide biosynthesis protein 2-like; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1; DPH like 1 (S. cerevisiae); DPH like 1; DPH-like 1; DPH1; DPH1 homolog (S. cerevisiae); DPH1 homolog; DPH1_HUMAN; DPH2 like 1; DPH2-like 1; DPH2L; DPH2L1; FLJ33211; HsDph1; Ovarian cancer associated gene 1; Ovarian cancer associated gene 1 protein; Ovarian cancer-associated gene 1 protein; Ovarian tumor suppressor candidate 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-443
  • 氨基酸序列
    MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA RPPSAVACED CSCRDEKVAP LAP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival.
  • 基因功能參考文獻:
    1. novel homozygous DPH1 mutation causes intellectual disability and unique craniofacial features PMID: 29410513
    2. We used WES to identify novel compound heterozygous mutations in DPH1 (c.289delG, p.Glu97Lysfs*8 and c.491T>C, p.Leu164Pro) in a patient from a nonconsanguineous family presenting with intellectual disability, a short stature, craniofacial abnormalities, and external genital abnormalities. PMID: 29362492
    3. DPH1 functions as an oncogene in CRC and can be negatively modulated by miR-218-5p to promote CRC tumourigenesis. PMID: 29145210
    4. Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. PMID: 26220823
    5. Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia. PMID: 24070652
    6. OVCA1 could inhibit the proliferation of ovarian cancer cells by p16/cyclin D1 pathway, but not by NF-kappaB PMID: 21487939

    顯示更多

    收起更多

  • 相關疾病:
    Developmental delay with short stature, dysmorphic features, and sparse hair (DEDSSH)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
  • 蛋白家族:
    DPH1/DPH2 family, DPH1 subfamily
  • 組織特異性:
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
  • 數據庫鏈接:

    HGNC: 3003

    OMIM: 603527

    KEGG: hsa:1801

    STRING: 9606.ENSP00000263083

    UniGene: Hs.513856



主站蜘蛛池模板: 3d动漫精品啪啪一区二区 | 在线观看无码av免费不卡软件| 亚洲日韩欧洲乱码av夜夜摸| 妺妺窝人体色www在线小说| 免费国产在线一区二区| 国语自产拍在线观看对白| 精品无码av一区二区三区不卡| 欧美午夜特黄aaaaaa片| 精品一区二区三人妻视频| 插插插精品亚洲一区| 少妇无码一区二区三区免费| 99久久人妻无码精品系列| 国产精品黄页免费高清在线观看| 精品久久久久久无码人妻vr| 美女视频黄频大全免费| 2018国产精华国产精品| 2020最新国产高清毛片| 中文字字幕在线精品乱码 | 狠狠躁夜夜躁人人爽天天5| 少妇高潮太爽了在线观看| 久久婷婷五月综合中文字幕| 亚洲6080yy久久无码产自国产 | 欧美日韩精品久久久免费观看| 亚洲日韩在线中文字幕综合| 丰满少妇高潮惨叫久久久| 国产精品一品二区三区的使用体验 | 日本韩国的免费观看视频| 狠狠做五月深爱婷婷伊人| 性欧美高清come| 亚洲人成网站日本片| 亚洲人成网站18禁止| 99在线在线视频观看| 亚洲中文字幕无码av| 亚洲丁香五月激情综合| 插一插射一射视频| 无码av中文字幕久久专区| 水蜜桃精品一二三| 无码加勒比一区二区三区四区| 熟妇好大好深好满好爽| av无码国产精品麻豆| 国产人妻精品一区二区三首|