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  4. DPH1 Antibody

DPH1 Antibody

  • 中文名稱：
    DPH1兔多克隆抗體
  • 貨號：
    CSB-PA007129GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Candidate tumor suppressor in ovarian cancer 1 antibody; Diphthamide biosynthesis protein 1 antibody; Diphthamide biosynthesis protein 2 homolog like 1 antibody; Diphthamide biosynthesis protein 2 homolog-like 1 antibody; Diphthamide biosynthesis protein 2 like antibody; Diphthamide biosynthesis protein 2-like antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody; DPH like 1 (S. cerevisiae) antibody; DPH like 1 antibody; DPH-like 1 antibody; DPH1 antibody; DPH1 homolog (S. cerevisiae) antibody; DPH1 homolog antibody; DPH1_HUMAN antibody; DPH2 like 1 antibody; DPH2-like 1 antibody; DPH2L antibody; DPH2L1 antibody; FLJ33211 antibody; HsDph1 antibody; Ovarian cancer associated gene 1 antibody; Ovarian cancer associated gene 1 protein antibody; Ovarian cancer-associated gene 1 protein antibody; Ovarian tumor suppressor candidate 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human OVCA1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival.
  • 基因功能參考文獻：
    1. novel homozygous DPH1 mutation causes intellectual disability and unique craniofacial features PMID: 29410513
    2. We used WES to identify novel compound heterozygous mutations in DPH1 (c.289delG, p.Glu97Lysfs*8 and c.491T>C, p.Leu164Pro) in a patient from a nonconsanguineous family presenting with intellectual disability, a short stature, craniofacial abnormalities, and external genital abnormalities. PMID: 29362492
    3. DPH1 functions as an oncogene in CRC and can be negatively modulated by miR-218-5p to promote CRC tumourigenesis. PMID: 29145210
    4. Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. PMID: 26220823
    5. Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia. PMID: 24070652
    6. OVCA1 could inhibit the proliferation of ovarian cancer cells by p16/cyclin D1 pathway, but not by NF-kappaB PMID: 21487939

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  • 相關(guān)疾病：
    Developmental delay with short stature, dysmorphic features, and sparse hair (DEDSSH)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
  • 蛋白家族：
    DPH1/DPH2 family, DPH1 subfamily
  • 組織特異性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3003

    OMIM: 603527

    KEGG: hsa:1801

    STRING: 9606.ENSP00000263083

    UniGene: Hs.513856



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