在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Differentially expressed in FDCP 6 homolog (DEF6)

  • 中文名稱:
    Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6)
  • 貨號:
    CSB-YP884467HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6)
  • 貨號:
    CSB-EP884467HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6)
  • 貨號:
    CSB-EP884467HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6)
  • 貨號:
    CSB-BP884467HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Differentially expressed in FDCP 6 homolog(DEF6)
  • 貨號:
    CSB-MP884467HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    DEF6
  • Uniprot No.:
  • 別名:
    DEF-6; Def6; DEFI6_HUMAN; Differentially expressed in FDCP 6 homolog; Differentially expressed in FDCP 6 homologue mouse; IBP; IRF4-binding protein; Swap70 like adapter of T cells
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-631
  • 氨基酸序列
    MALRKELLKS IWYAFTALDV EKSGKVSKSQ LKVLSHNLYT VLHIPHDPVA LEEHFRDDDD GPVSSQGYMP YLNKYILDKV EEGAFVKEHF DELCWTLTAK KNYRADSNGN SMLSNQDAFR LWCLFNFLSE DKYPLIMVPD EVEYLLKKVL SSMSLEVSLG ELEELLAQEA QVAQTTGGLS VWQFLELFNS GRCLRGVGRD TLSMAIHEVY QELIQDVLKQ GYLWKRGHLR RNWAERWFQL QPSCLCYFGS EECKEKRGII PLDAHCCVEV LPDRDGKRCM FCVKTANRTY EMSASDTRQR QEWTAAIQMA IRLQAEGKTS LHKDLKQKRR EQREQRERRR AAKEEELLRL QQLQEEKERK LQELELLQEA QRQAERLLQE EEERRRSQHR ELQQALEGQL REAEQARASM QAEMELKEEE AARQRQRIKE LEEMQQRLQE ALQLEVKARR DEESVRIAQT RLLEEEEEKL KQLMQLKEEQ ERYIERAQQE KEELQQEMAQ QSRSLQQAQQ QLEEVRQNRQ RADEDVEAAQ RKLRQASTNV KHWNVQMNRL MHPIEPGDKR PVTSSSFSGF QPPLLAHRDS SLKRLTRWGS QGNRTPSPNS NEQQKSLNGG DEAPAPASTP QEDKLDPAPE N
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling.
  • 基因功能參考文獻:
    1. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
    2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival. PMID: 27488395
    3. IBP was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases PMID: 23088770
    4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. PMID: 22829599
    5. Molecular cloning of IBP, a guanine nucleotide exchange factor, which is highly expressed in the immune system. PMID: 12651066
    6. IBP is a novel guanine nucleotide exchange factor and is recruited to the immunological synapse by T cell receptor engagement PMID: 12923183
    7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function PMID: 17121847
    8. level of expression correlates with the degree of malignancy in breast carcinoma tissues PMID: 19393345
    9. Overexpression of the Interferon regulatory factor 4-binding protein is associated with Colorectal Carcinoma. PMID: 19679060
    10. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA. PMID: 15023524

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
  • 組織特異性:
    Broadly expressed in the immune system and can be detected in T and B-cells.
  • 數據庫鏈接:

    HGNC: 2760

    OMIM: 610094

    KEGG: hsa:50619

    STRING: 9606.ENSP00000319831

    UniGene: Hs.15476



主站蜘蛛池模板: 亚洲国产美女精品久久久久| 色一情一区二| 动漫av永久无码精品每日更新 | 欧美一区二区三区激情| 国产清纯白嫩初高生在线观看| 国产成人av乱码免费观看| 无码写真精品永久福利在线| 97色伦午夜国产亚洲精品| 99久久精品免费看国产| 日韩成人一区二区三区在线观看| 国产精品一区波多野结衣| 日本少妇浓毛bbwbbwbbw| 777米奇色狠狠888俺也去乱| 亚洲欧洲免费无码| 国产高潮抽搐喷水高清| 成年片色大黄全免费网站久久高潮| 无码丰满少妇2在线观看| 日日狠狠久久8888偷偷色| 亚洲熟妇av午夜无码不卡| 强奷妇系列中文字幕| 国产午夜福利短视频| 中文字幕精品久久久久人妻红杏ⅰ| 国产精品aⅴ在线观看| 柠檬福利第一导航在线| 国产精品久久久久久久久动漫| 久久天天躁夜夜躁狠狠i女人| 人人妻人人澡人人爽欧美精品| 亚洲色一区二区三区四区| 久久99精品国产麻豆婷婷| 影音先锋人妻每日资源站| 无码潮喷a片无码高潮视频| 18禁裸体女免费观看| 久久久久久久岛国免费观看 | 亚洲人成网亚洲欧洲无码| 高清无码午夜福利视频| 亚洲成a人v在线蜜臀| 国产乱人伦偷精精品视频| 动漫精品啪啪一区二区三区| 8x福利精品第一导航| 少妇午夜av一区| 天堂а√中文在线官网|