在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Dedicator of cytokinesis protein 3 (DOCK3), partial

Recombinant Human Dedicator of cytokinesis protein 3 (DOCK3), partial

  • 中文名稱(chēng)：
    人DOCK3重組蛋白
  • 貨號(hào)：
    CSB-YP818270HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    人DOCK3重組蛋白
  • 貨號(hào)：
    CSB-EP818270HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    人DOCK3重組蛋白
  • 貨號(hào)：
    CSB-EP818270HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    人DOCK3重組蛋白
  • 貨號(hào)：
    CSB-BP818270HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    人DOCK3重組蛋白
  • 貨號(hào)：
    CSB-MP818270HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DOCK3
  • Uniprot No.：
  • 別名：
    DOCK3; KIAA0299; MOCADedicator of cytokinesis protein 3; Modifier of cell adhesion; Presenilin-binding protein; PBP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
  • 基因功能參考文獻(xiàn)：
    1. here we report a second case of biallelic DOCK3 mutation due to homozygous deletion. Given the clinical similarities among the cases with DOCK3 mutations, we provided further evidence that biallelic mutations of DOCK3 lead to a specific DOCK3-related neurodevelopmental syndrome PMID: 29130632
    2. Common features in both affected individuals include severe developmental disability, ataxic gait, and severe hypotonia, which recapitulates the Dock3 knockout mouse phenotype. We show that complete DOCK3 deficiency in humans leads to developmental disability with significant hypotonia and gait ataxia, probably due to abnormal axonal development PMID: 28195318
    3. Inhibition of Dock3 by Dock3 shRNA impaired the severity of status epilepticus in the acute stage and decreased the spontaneous recurrent seizures times in the chronic stage of lithium-pilocarpine model and decreased the expression of rac1-GTP. PMID: 26319681
    4. Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines. PMID: 25687035
    5. It plays a role in axonal regeneration. (review) PMID: 22746061
    6. MOCA is a key molecule of the Alzheimer disease-relevant neuronal death signals that links the presenilin-mediated death signal with the APP-mediated death signal at a point between Rac1 or Cdc42 and ASK1. PMID: 22115042
    7. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex PMID: 20368433
    8. We report that MOCA modulates cell-cell adhesion and morphology by increasing the accumulation of adherens junction proteins. PMID: 15647471
    9. MOCA is a novel Wnt negative regulator and demonstrate that this screening approach can be a rapid means for isolation of new Wnt regulators. PMID: 18716063

    顯示更多

    收起更多

  • 相關(guān)疾病：
    A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2989

    OMIM: 603123

    KEGG: hsa:1795

    STRING: 9606.ENSP00000266037

    UniGene: Hs.476284



主站蜘蛛池模板： 日产精品卡二卡三卡四卡乱码视频| 成人天堂资源www在线| 国产三级精品三级在专区| 成 人 综合 亚洲另类| 久久精品日日躁夜夜躁| 伊人久久大香线蕉亚洲五月天| 少妇人妻偷人精品一区二区| 色欲色香天天天综合无码| 天堂网在线www资源| 免费网站观看www在线观看| 亚洲乱码日产精品bd在线观看| 麻豆国产在线精品国偷产拍| 综合激情五月综合激情五月激情1| 久久综合九色综合97欧美| 朝鲜女人大白屁股ass| 欧美成aⅴ人高清免费| 黑人巨大av无码专区| 国产卡一卡二卡三无线乱码新区| 在线观看国产成人av天堂| 在线视频免费无码专区| 中文毛片无遮挡高潮免费| 大伊香蕉精品视频在线天堂| 久久亚洲精品无码爱剪辑| 久久综合久中文字幕青草| 九九久久精品无码专区| 少妇高潮太爽了在线观看| 亚洲综合天堂一区二区三区 | 人妻av中文字幕久久| 日韩无码专区| 欧美亚洲色aⅴ大片| 亚洲欧洲精品成人久久曰影片| 久久久久久久久久久国产| 免费夫妻生活片av| 色八区人妻在线视频免费| 可以直接看的无码av| 国模无码人体一区二区| 又粗又黄又猛又爽大片免费| 成人免费无码大片a毛片小说 | 无码人妻巨屁股系列| 小泽玛利亚一区二区在线观看| 日韩亚洲欧美中文在线|