在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DOCK3 Antibody, HRP conjugated

DOCK3 Antibody, HRP conjugated

  • 中文名稱：
    DOCK3兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA818270LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DOCK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DOCK3
  • 別名：
    DOCK3 antibody; KIAA0299 antibody; MOCADedicator of cytokinesis protein 3 antibody; Modifier of cell adhesion antibody; Presenilin-binding protein antibody; PBP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 3 protein (1630-1934AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
  • 基因功能參考文獻：
    1. here we report a second case of biallelic DOCK3 mutation due to homozygous deletion. Given the clinical similarities among the cases with DOCK3 mutations, we provided further evidence that biallelic mutations of DOCK3 lead to a specific DOCK3-related neurodevelopmental syndrome PMID: 29130632
    2. Common features in both affected individuals include severe developmental disability, ataxic gait, and severe hypotonia, which recapitulates the Dock3 knockout mouse phenotype. We show that complete DOCK3 deficiency in humans leads to developmental disability with significant hypotonia and gait ataxia, probably due to abnormal axonal development PMID: 28195318
    3. Inhibition of Dock3 by Dock3 shRNA impaired the severity of status epilepticus in the acute stage and decreased the spontaneous recurrent seizures times in the chronic stage of lithium-pilocarpine model and decreased the expression of rac1-GTP. PMID: 26319681
    4. Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines. PMID: 25687035
    5. It plays a role in axonal regeneration. (review) PMID: 22746061
    6. MOCA is a key molecule of the Alzheimer disease-relevant neuronal death signals that links the presenilin-mediated death signal with the APP-mediated death signal at a point between Rac1 or Cdc42 and ASK1. PMID: 22115042
    7. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex PMID: 20368433
    8. We report that MOCA modulates cell-cell adhesion and morphology by increasing the accumulation of adherens junction proteins. PMID: 15647471
    9. MOCA is a novel Wnt negative regulator and demonstrate that this screening approach can be a rapid means for isolation of new Wnt regulators. PMID: 18716063

    顯示更多

    收起更多

  • 相關(guān)疾病：
    A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2989

    OMIM: 603123

    KEGG: hsa:1795

    STRING: 9606.ENSP00000266037

    UniGene: Hs.476284



主站蜘蛛池模板： 久久亚洲熟女cc98cm| 天天做天天爱夜夜爽毛片| 国产在线一区二区在线视频 | 在线永久无码不卡av| 欧美人与动另类xxxx| 国产亚洲日韩欧美一区二区三区| 99久久精品免费看国产一区二区| 午夜免费啪视频在线观看区| 丁香婷婷综合激情五月色| 天堂8在线新版官网| 国产成人综合亚洲色就色| 亚洲2020天天堂在线观看| 欧美人妻少妇精品久久黑人 | 国产精品国产自线拍免费不卡| 男人扒开女人双腿猛进免费视频| 色妺妺视频网| 人人妻人人爽人人做夜欢视频| 野外少妇被弄到喷水在线观看| 好紧好爽好深再快点av在线| 国产精品人人妻人人爽人人牛| 国产精品99久久久久久www| 无码国产激情在线观看| 2021自拍偷在线精品自拍偷| 未满小14洗澡无码视频网站| 色爱情人网站| 2018高清日本一道国产-在| 中国china露脸自拍性hd| 一线二线三线天堂| 午夜免费啪视频在线18| 无码少妇一区二区浪潮av| 午夜亚洲www湿好爽| 亚洲中文字幕无码mv| 手机看片精品国产福利| 亚洲色一区二区三区四区| 人妻熟女一二三区夜夜爱| 亚洲欧洲成人a∨在线观看| 国产女女做受ⅹxx高潮| 欧美性大战久久久久久| 日本免码va在线看免费| 曰批视频免费30分钟成人 | 夜夜高潮夜夜爽夜夜爱爱一区|