在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DOCK3 Antibody, Biotin conjugated

DOCK3 Antibody, Biotin conjugated

  • 中文名稱：
    DOCK3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA818270LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DOCK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DOCK3
  • 別名：
    DOCK3 antibody; KIAA0299 antibody; MOCADedicator of cytokinesis protein 3 antibody; Modifier of cell adhesion antibody; Presenilin-binding protein antibody; PBP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dedicator of cytokinesis protein 3 protein (1630-1934AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.
  • 基因功能參考文獻(xiàn)：
    1. here we report a second case of biallelic DOCK3 mutation due to homozygous deletion. Given the clinical similarities among the cases with DOCK3 mutations, we provided further evidence that biallelic mutations of DOCK3 lead to a specific DOCK3-related neurodevelopmental syndrome PMID: 29130632
    2. Common features in both affected individuals include severe developmental disability, ataxic gait, and severe hypotonia, which recapitulates the Dock3 knockout mouse phenotype. We show that complete DOCK3 deficiency in humans leads to developmental disability with significant hypotonia and gait ataxia, probably due to abnormal axonal development PMID: 28195318
    3. Inhibition of Dock3 by Dock3 shRNA impaired the severity of status epilepticus in the acute stage and decreased the spontaneous recurrent seizures times in the chronic stage of lithium-pilocarpine model and decreased the expression of rac1-GTP. PMID: 26319681
    4. Results supported that miR-512-3p could inhibit tumor cell adhesion, migration, and invasion by regulating the RAC1 activity via DOCK3 in NSCLC A549 and H1299 cell lines. PMID: 25687035
    5. It plays a role in axonal regeneration. (review) PMID: 22746061
    6. MOCA is a key molecule of the Alzheimer disease-relevant neuronal death signals that links the presenilin-mediated death signal with the APP-mediated death signal at a point between Rac1 or Cdc42 and ASK1. PMID: 22115042
    7. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex PMID: 20368433
    8. We report that MOCA modulates cell-cell adhesion and morphology by increasing the accumulation of adherens junction proteins. PMID: 15647471
    9. MOCA is a novel Wnt negative regulator and demonstrate that this screening approach can be a rapid means for isolation of new Wnt regulators. PMID: 18716063

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9.
  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    DOCK family
  • 組織特異性：
    In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2989

    OMIM: 603123

    KEGG: hsa:1795

    STRING: 9606.ENSP00000266037

    UniGene: Hs.476284



主站蜘蛛池模板： 午夜射精日本三级| 97久久超碰国产精品旧版麻豆| 性开放的欧美大片| 日本夜爽爽一区二区三区 | 中文字幕人妻伦伦| 欧美亚洲日本国产黑白配| 亚洲爆乳aaa无码专区| 亚洲爆乳精品无码一区二区| 亚洲人成人网站色www| 无码手机线免费观看| 亚洲国产欧美在线观看片不卡| 精品97国产免费人成视频| 亚洲精品无码久久久久| 午夜福利一区二区三区高清视频 | 天天躁日日躁狠狠躁av麻豆男男| 无码人妻丰满熟妇区五十路| 无码人妻精品一区二区三区免费| 国产精品免费久久久久软件| 欧美 变态 另类 人妖| 一本一道av无码中文字幕| 五月综合缴情婷婷六月| 少妇人妻在线视频| 亚洲精品国产品国语在线| 极品美女在线观看免费直播| 国产av巨作丝袜秘书| 国产一性一交一伦一a片| 羞羞视频在线观看| 蜜臀av国产精品久久久久| 国产午夜精品无码一区二区| 成人亚洲欧美成αⅴ人在线观看| 中文字幕v亚洲日本在线| 国产作爱视频免费播放| 欧美成人精品三级网站| 亚洲中文色欧另类欧美| 国产精品va在线观看丝瓜影院| 亚洲日本va中文字幕久久| 人妻丰满熟妇无码区免费| 亚洲一线产区二线产区分布| 成人性生交大免费看| 亚洲国产天堂久久综合| 亚洲日本中文字幕乱码在线 |