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  4. Recombinant Human DNA replication licensing factor MCM8 (MCM8), partial

Recombinant Human DNA replication licensing factor MCM8 (MCM8), partial

  • 中文名稱：
    人MCM8重組蛋白
  • 貨號：
    CSB-YP890907HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MCM8重組蛋白
  • 貨號：
    CSB-EP890907HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MCM8重組蛋白
  • 貨號：
    CSB-EP890907HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MCM8重組蛋白
  • 貨號：
    CSB-BP890907HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MCM8重組蛋白
  • 貨號：
    CSB-MP890907HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MCM8
  • Uniprot No.：
  • 別名：
    C20orf154 ; dJ967N21.5; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8; MCM8_HUMAN; MGC119522 ; MGC119523 ; MGC12866 ; MGC4816 ; Minichromosome maintenance 8; Minichromosome maintenance complex component 8; REC
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
  • 基因功能參考文獻：
    1. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype. PMID: 28863940
    2. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    3. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development. PMID: 28481876
    4. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    5. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair. PMID: 27573988
    6. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia. PMID: 26823731
    7. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These PMID: 25873734
    8. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability. PMID: 25437880
    9. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    10. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause. PMID: 22696150
    11. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan. PMID: 22131368
    12. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13. PMID: 12771218
    13. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly. PMID: 15684404
    14. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase. PMID: 18072282

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  • 相關疾病：
    Premature ovarian failure 10 (POF10)
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    MCM family
  • 組織特異性：
    Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
  • 數據庫鏈接：

    HGNC: 16147

    OMIM: 608187

    KEGG: hsa:84515

    STRING: 9606.ENSP00000368174

    UniGene: Hs.597484



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