在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCM8 Antibody

MCM8 Antibody

  • 中文名稱：
    MCM8兔多克隆抗體
  • 貨號：
    CSB-PA013598GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MCM8
  • 別名：
    C20orf154 antibody; dJ967N21.5 antibody; DNA helicase MCM8 antibody; DNA replication licensing factor MCM8 antibody; MCM8 antibody; MCM8_HUMAN antibody; MGC119522 antibody; MGC119523 antibody; MGC12866 antibody; MGC4816 antibody; Minichromosome maintenance 8 antibody; Minichromosome maintenance complex component 8 antibody; REC antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human MCM8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
  • 基因功能參考文獻(xiàn)：
    1. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype. PMID: 28863940
    2. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    3. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development. PMID: 28481876
    4. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    5. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair. PMID: 27573988
    6. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia. PMID: 26823731
    7. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These PMID: 25873734
    8. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability. PMID: 25437880
    9. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    10. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause. PMID: 22696150
    11. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan. PMID: 22131368
    12. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13. PMID: 12771218
    13. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly. PMID: 15684404
    14. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase. PMID: 18072282

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Premature ovarian failure 10 (POF10)
  • 亞細(xì)胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    MCM family
  • 組織特異性：
    Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16147

    OMIM: 608187

    KEGG: hsa:84515

    STRING: 9606.ENSP00000368174

    UniGene: Hs.597484



主站蜘蛛池模板： 国产98色在线 | 国产| 亚洲综合色视频在线观看| 色婷婷综合久久久久中文| 久久aⅴ无码av高潮av喷吹| 日韩新无码精品毛片| 色视频无码专区在线观看| 国产曰批免费视频播放免费| 国产精品美女久久久| 偷看少妇自慰xxxx| 国产在线一区二区在线视频| 久久97久久97精品免视看| 女人高潮内射99精品| 香港台湾经典三级a视频| 国产丰满麻豆vⅰde0sex| 国产99久久久欧美黑人刘玥 | 国产精品特级毛片一区二区三区| 欧美高清性色生活片免费观看| 无码8090精品久久一区| 久久99精品国产99久久6不卡| 特大巨黑吊xxxx高潮| 国产精品老熟女露脸视频| 亚洲精品无码伊人久久| 中文字幕人妻互换av久久| 成人欧美日韩一区二区三区| 成人电线在线播放无码| 乱人伦中文无码视频| 国産精品久久久久久久| 免费无码午夜福利片| 好爽好湿好硬好大免费视频| 久久久精品日本一区二区三区| 一本色道无码道dvd在线观看| 少妇一边呻吟一边说使劲| 2019午夜福利不卡片在线| 国产精品精华液网站| 国产激情无码视频在线播放| 肉色丝袜足j视频国产| 久久99精品久久久大学生| 成人看片黄a免费看在线| 一区二区三区四区在线不卡高清| 在线欧美中文字幕农村电影| 色综合久久中文娱乐网|