在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCM8 Antibody, HRP conjugated

MCM8 Antibody, HRP conjugated

  • 中文名稱：
    MCM8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA890907LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MCM8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MCM8
  • 別名：
    C20orf154 antibody; dJ967N21.5 antibody; DNA helicase MCM8 antibody; DNA replication licensing factor MCM8 antibody; MCM8 antibody; MCM8_HUMAN antibody; MGC119522 antibody; MGC119523 antibody; MGC12866 antibody; MGC4816 antibody; Minichromosome maintenance 8 antibody; Minichromosome maintenance complex component 8 antibody; REC antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA helicase MCM8 protein (1-67AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Probably by regulating HR, plays a key role during gametogenesis. Stabilizes MCM9 protein.
  • 基因功能參考文獻：
    1. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype. PMID: 28863940
    2. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase. PMID: 28487407
    3. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development. PMID: 28481876
    4. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes. PMID: 27802094
    5. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair. PMID: 27573988
    6. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia. PMID: 26823731
    7. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These PMID: 25873734
    8. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability. PMID: 25437880
    9. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment. PMID: 23401855
    10. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause. PMID: 22696150
    11. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan. PMID: 22131368
    12. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13. PMID: 12771218
    13. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly. PMID: 15684404
    14. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase. PMID: 18072282

    顯示更多

    收起更多

  • 相關疾病：
    Premature ovarian failure 10 (POF10)
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    MCM family
  • 組織特異性：
    Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
  • 數據庫鏈接：

    HGNC: 16147

    OMIM: 608187

    KEGG: hsa:84515

    STRING: 9606.ENSP00000368174

    UniGene: Hs.597484



主站蜘蛛池模板： 邪恶肉肉全彩色无遮盖| 亚洲国产一区二区波多野结衣| 亚洲国产精品尤物yw在线 | 午夜性色吃奶添下面69影院 | 色妞色视频一区二区三区四区| 亚洲第一成年免费网站| 亚洲精品午夜无码电影网| 亚洲欧美乱综合图片区小说区 | 日本肉体xxxx裸体137大胆| 久久青青草原国产最新片完整| 欲色欲色天天天www| 国产精品午夜无码av体验区| 亚洲日韩国产二区无码| 非洲黑人性xxxx精品| 人妻无码中字在线a| 狠狠cao日日穞夜夜穞av| 丰满少妇作爱视频免费观看| 4480yy私人精品国产| 人人爽人人爽人人爽| 中国女人内谢69xxxx| 内射巨臀欧美在线视频| 西欧free性满足hd| 日本猛少妇色xxxxx猛叫| 欧美牲交a欧美在线| 亚洲爆乳成av人在线视菜奈实| 午夜嘿嘿嘿影院| 香港三日本8a三级少妇三级99| 免费情侣作爱视频| 亚洲日韩国产一区二区三区在线| 国产午夜手机精彩视频| 无码专区人妻系列日韩精品| 久久综合久久自在自线精品自| 综合亚洲桃色第一影院| 97色伦图片97综合影院| 色综合天天综合天天更新| 久久精品免费一区二区三区| 久久精品国产99精品国产2021 | 五月婷婷俺也去开心| 久久老子午夜精品无码怎么打| 亚洲精品偷拍影视在线观看| 欧美乱妇高清无乱码在线观看|