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  4. Recombinant Human DDB1- and CUL4-associated factor 6 (DCAF6), partial

Recombinant Human DDB1- and CUL4-associated factor 6 (DCAF6), partial

  • 中文名稱：
    Recombinant Human DDB1- and CUL4-associated factor 6(DCAF6) ,partial
  • 貨號：
    CSB-YP685382HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human DDB1- and CUL4-associated factor 6(DCAF6) ,partial
  • 貨號：
    CSB-EP685382HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human DDB1- and CUL4-associated factor 6(DCAF6) ,partial
  • 貨號：
    CSB-EP685382HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human DDB1- and CUL4-associated factor 6(DCAF6) ,partial
  • 貨號：
    CSB-BP685382HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human DDB1- and CUL4-associated factor 6(DCAF6) ,partial
  • 貨號：
    CSB-MP685382HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DCAF6
  • Uniprot No.：
  • 別名：
    1200006M05Rik; Androgen receptor complex associated protein; Androgen receptor complex-associated protein; ARCAP; DCAF6; DCAF6_HUMAN; DDB1 and CUL4 associated factor 6; DDB1- and CUL4-associated factor 6; IQ motif and WD repeat-containing protein 1; IQ motif and WD repeats 1; IQWD1; MSTP055; NRIP; Nuclear receptor interaction protein; RP4 745I14.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
  • 基因功能參考文獻：
    1. High IQWD1 expression is associated with breast cancer. PMID: 24222117
    2. NRIP enhances HPV 16 gene expression via interaction with either GR or viral E2. PMID: 22177699
    3. NRIP interacts with either androgen or glucocorticoid receptors PMID: 15784617
    4. NRIP plays a feed-forward role enhancing androgen receptor (AR)-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation. PMID: 17984071
    5. A survey results showed that ten cancer cases were revealed to express the NRIP in six malignancies, but not all of these specific tumor types consistently showed positive NRIP expression. PMID: 18673574

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.
  • 數據庫鏈接：

    HGNC: 30002

    OMIM: 610494

    KEGG: hsa:55827

    STRING: 9606.ENSP00000356814

    UniGene: Hs.435741



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