在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Cysteine dioxygenase type 1 (CDO1)

In Stock
  • 中文名稱:
    Recombinant Human Cysteine dioxygenase type 1 (CDO1)
  • 貨號:
    CSB-EP621975HUf0
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    CDO1
  • Uniprot No.:
  • 別名:
    Cysteine dioxygenase type I;CDO;CDO-I
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    54.5 kDa
  • 表達(dá)區(qū)域:
    1-200aa
  • 氨基酸序列
    MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal GST-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
  • 基因功能參考文獻(xiàn):
    1. High CDO1 methylation is associated with colorectal cancer progression. PMID: 29746493
    2. Promoter NA methylation of CDO1 was demonstrated for the first time to be a cancer-associated methylation in primary gallbladder cancer(GBC), and it has the potential to be a prognostic biomarker of GBC for high-risk patients with stage II GBC. PMID: 29161283
    3. CDO1 methylation could be a potent prognostic predictor in primary esophageal squamous cell carcinoma and have great potential as a prognostic factor to guide the treatment of patients who need adjuvant chemotherapy. PMID: 27629777
    4. High methylation of CDO1 gene is responsible of the development of the esophageal adenocarcinoma. PMID: 28184414
    5. CDO1 promoter methylation is involved in gene regulation and is a potential prognostic biomarker for BCR-free survival in prostate cancer (PC) patients following radical prostatectomy. Further studies are needed to validate CDO1 methylation assays and to evaluate the clinical utility of CDO1 methylation for the management of PCa PMID: 27689475
    6. methylation of the CDO1 gene promoter could be strong prognostic indicator in primary BC without preoperative treatment. PMID: 26785325
    7. CDO1 promoter methylation may not substitute common prognostic makers to predict ccRCC survival, but offers additional, relevant prognostic information, indicating that it might be a novel molecular marker to determine ccRCC prognosis PMID: 25904753
    8. Decreased expression of CDO1 is associated with esophageal squamous cell carcinoma. PMID: 25903467
    9. A structural role of the Cys-Tyr cofactor coordinates the ferrous iron in the active site of CDO1. PMID: 25261132
    10. A high negative correlation between promoter DNA methylation and gene expression was observed for CDO1, ZNF331 and ZSCAN18 in gastrointestinal tumors. PMID: 24948044
    11. TGF-b1 suppressed Cdo1 gene transcription through the MEK/ERK pathway. PMID: 24553827
    12. we define a three-gene panel, CDO1, HOXA9, and TAC1, which we subsequently validate in two independent cohorts of primary NSCLC samples PMID: 24486589
    13. methylation status of serum CDO1 gene promoter may be helpful in the diagnosis of hepatocellular carcinoma (HCC) and the estimation of the HCC stages. PMID: 24646840
    14. Our study shows the importance of CDO1 inactivation in breast cancer and its clinical potential as a biomarker and therapeutic target to overcome resistance to anthracyclines. PMID: 23630167
    15. CDO1 as a novel tumor suppressor gene and a potentially valuable molecular marker for human cancer PMID: 23028699
    16. We confirmed that the expression of CDO1 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region. PMID: 22011669
    17. Cysteine dioxygenase contains a 3His ligand motif rather than 2His/1Asp. The former is essential for optimal dioxygenation activity. Mutants with a 2His/1Asp motif may give sulfoxides as byproduct due to incomplete dioxygenation. PMID: 19199799
    18. DNA methylation of CDO1 predicted distant recurrence in lymph node-positive patients with estrogen receptor-positive tumors treated with adjuvant anthracycline containing therapy. PMID: 20515469
    19. CDO is capable of altering intracellular cysteine levels as well as glutathione levels. PMID: 17327371
    20. Upon comparison of PBMC and skin samples of Sezary syndrome versus mycosis fungoides, CDO1 and DNM3 were found upregulated only in Sezary syndrome. PMID: 18033314

    顯示更多

    收起更多

  • 蛋白家族:
    Cysteine dioxygenase family
  • 組織特異性:
    Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1795

    OMIM: 603943

    KEGG: hsa:1036

    STRING: 9606.ENSP00000250535

    UniGene: Hs.442378



主站蜘蛛池模板: 最新网站亚洲人成无码| 三叶草欧洲码在线| 欧美日韩国产一区二区三区不卡| 老司机久久一区二区三区| 亚洲欧美日韩另类精品一区| 一本一道波多野结衣av中文| 米奇影视第四色| 久久亚洲国产精品123区| 蜜桃少妇av久久久久久久| 国产精品久久久久久久免费看| 波多野结衣 黑人| 人妻综合专区第一页| av一区二区国产在线视频| 中文字幕无码免费久久| 日本丰满少妇xxxx| 国产萌白酱喷水视频在线播放 | 亚洲伊人久久综合影院| 欧洲性久久精品| 亚洲综合无码av一区二区三区| 亚洲成a人无码| 日本高清在线一区二区三区| 正在播放国产真实哭都没用| 国产98在线 | 免费| 欧美另类videossexo高潮| 中文字幕精品无码一区二区| 亚洲爆乳成av人在线视菜奈实| 亚洲aⅴ无码专区在线观看q| 野狼av午夜福利在线| 国产精品毛片完整版视频| 国产男生夜间福利免费网站| 欧美大荫蒂毛茸茸视频| 无码av一区二区三区无码| av大片在线无码永久免费| 女学生14毛片视频片二毛| 中国白嫩丰满人妻videos| 亚洲乱亚洲乱少妇无码99p| 少妇仑乱a毛片无码| 日本丰满人妻xxxxxhd| 日日噜噜噜夜夜爽爽狠狠| 秋霞人妻无码中文字幕| 麻豆果冻传媒2021精品传媒一区下载|