在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDO1 Antibody

  • 中文名稱:
    CDO1兔多克隆抗體
  • 貨號:
    CSB-PA621975ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA621975ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA621975ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CDO1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CDO1
  • 別名:
    CDO 1 antibody; CDO antibody; CDO I antibody; CDO-I antibody; Cdo1 antibody; CDO1_HUMAN antibody; CDOI antibody; Cysteine dioxygenase type 1 antibody; Cysteine dioxygenase type I antibody; Cytosolic cysteine dioxygenase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cysteine dioxygenase type 1 protein (1-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
  • 基因功能參考文獻:
    1. High CDO1 methylation is associated with colorectal cancer progression. PMID: 29746493
    2. Promoter NA methylation of CDO1 was demonstrated for the first time to be a cancer-associated methylation in primary gallbladder cancer(GBC), and it has the potential to be a prognostic biomarker of GBC for high-risk patients with stage II GBC. PMID: 29161283
    3. CDO1 methylation could be a potent prognostic predictor in primary esophageal squamous cell carcinoma and have great potential as a prognostic factor to guide the treatment of patients who need adjuvant chemotherapy. PMID: 27629777
    4. High methylation of CDO1 gene is responsible of the development of the esophageal adenocarcinoma. PMID: 28184414
    5. CDO1 promoter methylation is involved in gene regulation and is a potential prognostic biomarker for BCR-free survival in prostate cancer (PC) patients following radical prostatectomy. Further studies are needed to validate CDO1 methylation assays and to evaluate the clinical utility of CDO1 methylation for the management of PCa PMID: 27689475
    6. methylation of the CDO1 gene promoter could be strong prognostic indicator in primary BC without preoperative treatment. PMID: 26785325
    7. CDO1 promoter methylation may not substitute common prognostic makers to predict ccRCC survival, but offers additional, relevant prognostic information, indicating that it might be a novel molecular marker to determine ccRCC prognosis PMID: 25904753
    8. Decreased expression of CDO1 is associated with esophageal squamous cell carcinoma. PMID: 25903467
    9. A structural role of the Cys-Tyr cofactor coordinates the ferrous iron in the active site of CDO1. PMID: 25261132
    10. A high negative correlation between promoter DNA methylation and gene expression was observed for CDO1, ZNF331 and ZSCAN18 in gastrointestinal tumors. PMID: 24948044
    11. TGF-b1 suppressed Cdo1 gene transcription through the MEK/ERK pathway. PMID: 24553827
    12. we define a three-gene panel, CDO1, HOXA9, and TAC1, which we subsequently validate in two independent cohorts of primary NSCLC samples PMID: 24486589
    13. methylation status of serum CDO1 gene promoter may be helpful in the diagnosis of hepatocellular carcinoma (HCC) and the estimation of the HCC stages. PMID: 24646840
    14. Our study shows the importance of CDO1 inactivation in breast cancer and its clinical potential as a biomarker and therapeutic target to overcome resistance to anthracyclines. PMID: 23630167
    15. CDO1 as a novel tumor suppressor gene and a potentially valuable molecular marker for human cancer PMID: 23028699
    16. We confirmed that the expression of CDO1 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region. PMID: 22011669
    17. Cysteine dioxygenase contains a 3His ligand motif rather than 2His/1Asp. The former is essential for optimal dioxygenation activity. Mutants with a 2His/1Asp motif may give sulfoxides as byproduct due to incomplete dioxygenation. PMID: 19199799
    18. DNA methylation of CDO1 predicted distant recurrence in lymph node-positive patients with estrogen receptor-positive tumors treated with adjuvant anthracycline containing therapy. PMID: 20515469
    19. CDO is capable of altering intracellular cysteine levels as well as glutathione levels. PMID: 17327371
    20. Upon comparison of PBMC and skin samples of Sezary syndrome versus mycosis fungoides, CDO1 and DNM3 were found upregulated only in Sezary syndrome. PMID: 18033314

    顯示更多

    收起更多

  • 蛋白家族:
    Cysteine dioxygenase family
  • 組織特異性:
    Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
  • 數據庫鏈接:

    HGNC: 1795

    OMIM: 603943

    KEGG: hsa:1036

    STRING: 9606.ENSP00000250535

    UniGene: Hs.442378



主站蜘蛛池模板: 亚洲欧洲日产国码韩国| 国产成人综合久久亚洲精品| 放荡的美妇在线播放| 国产精品白丝久久av网站| 亚洲精品久久av无码麻| 欧美xxxxx精品| 国产精品对白交换视频| 国产一区二区怡红院| 狠狠色丁香久久婷婷综合_中| 激情影院内射美女| 国产精品久久久久9999小说| 特黄做受又硬又粗又大视频小说| 久久高清超碰av热热久久| 天天爽夜夜爽人人爽曰| 国产在线aaa片一区二区99| 人妻三级日本香港三级极| 免费无码久久成人网站入口| 99久久人妻无码精品系列蜜桃| 99久久精品国产一区二区三区| 精品国产乱码久久久久久1区2区| 97超碰精品成人国产| 青青草国产三级精品三级| 欧美丰满熟妇bbb久久久| 午夜寂寞少妇aaa片毛片| 免费h动漫无码网站| 国产卡一卡二卡三精品| 亚洲精品久久一区二区三区777| 天天爽夜夜爽夜夜爽| 免费人成网站视频在线观看| 亚洲日韩av无码| 婷婷无套内射影院| 中文字幕中文有码在线| 国产高清国产精品国产专区| 国产96在线 | 亚洲| 少妇人妻综合久久中文字幕| 免费国产成人高清在线视频| 人妻熟女一区二区三区app下载| 亚洲国产成人久久精品大牛影视| 久久香蕉国产线看观看手机| 大伊香蕉精品视频在线直播| 少妇私密会所按摩到高潮呻吟|