在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-YP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-BP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-MP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COL25A1
  • Uniprot No.：
  • 別名：
    COL25A1Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component; CLAC)]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
  • 基因功能參考文獻：
    1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
    2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
    3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
    4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
    5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
    6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
    7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
    8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
    9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
    10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
    11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
  • 組織特異性：
    Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18603

    OMIM: 610004

    KEGG: hsa:84570

    STRING: 9606.ENSP00000382083

    UniGene: Hs.658842



主站蜘蛛池模板： 中文字幕av伊人av无码av| 水蜜桃精品一二三| 欧美色欧美亚洲日韩在线播放| 超薄丝袜足j好爽在线观看| 2020精品国产a不卡片| 久久国产av影片| 亚洲加勒比无码一区二区| 国产精品人妻一码二码尿失禁| 波多野结衣中文字幕久久 | 中文字幕v亚洲日本在线| 免费看国产成年无码av| 亚洲欧美不卡高清在线| 午夜大片免费男女爽爽影院| 性生交大全免费看| 人人玩人人添人人澡超碰偷拍| 日本一道一区二区视频| 欧洲精品卡一卡二卡三| 色噜噜一区二区三区| 肥臀浪妇太爽了快点再快点| 亚洲制服丝袜av一区二区三区| 午夜内射中出视频| 久久久久久久久久久综合日本| 欧美日韩精品一区二区在线播放| 久久er99热精品一区二区| 亚洲中文字幕日产乱码在线| 国产精品亚洲二区在线看| 天堂а在线中文在线新版| 国产免费内射又粗又爽密桃视频| 午夜理论在线观看不卡大地影院| 99久久亚洲综合精品成人| 2020久热爱精品视频在线观看| 无码区国产区在线播放| 97无码免费人妻超级碰碰夜夜| aaa欧美色吧激情视频| 午夜dj在线观看高清在线视频完整版| а天堂中文在线官网| 国产精品高潮呻吟av久久4虎| 国产女人高潮抽搐叫床视频| 欧美日韩亚洲国产在线制服| 国产激情久久久久久熟女老人| 日本丰满妇人成熟免费中文字幕|