在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-YP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-BP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-MP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COL25A1
  • Uniprot No.：
  • 別名：
    COL25A1Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component; CLAC)]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
  • 基因功能參考文獻：
    1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
    2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
    3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
    4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
    5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
    6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
    7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
    8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
    9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
    10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
    11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
  • 組織特異性：
    Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18603

    OMIM: 610004

    KEGG: hsa:84570

    STRING: 9606.ENSP00000382083

    UniGene: Hs.658842



主站蜘蛛池模板： 人妻熟女一区二区三区app下载| 国产无套粉嫩白浆在线| 亚洲国产中文曰韩丝袜| 欧美国产日本高清不卡| 97色偷偷色噜噜狠狠爱网站| 24小时日本在线www免费的| 国产强奷在线播放免费| 亚洲视频日韩视欧美视频| 午夜家庭影院| 成年无码动漫av片在线观看羞羞| 国产重口老太和小伙乱| 朝鲜女子内射杂交bbw| 久久中文字幕人妻熟av女| 欧美日韩人人模人人爽人人喊| 亚洲无日韩码精品| 日日摸日日碰夜夜爽亚洲| 国产黄大片在线观看画质优化| 色狠狠av一区二区三区| 一本大道无码av天堂| 鲁死你av资源站| 久久精品动漫一区二区三区| 欧美一道本一区二区三区| 国产美女遭强高潮网站下载| 中文字幕乱码人妻无码久久| а√天堂资源中文在线官网| 国产成人精品a∨一区二区| 国产女人乱人伦精品一区二区| 色偷偷88888欧美精品久久久| 亚洲日本va午夜中文字幕久久 | a毛片免费全部播放| 97高清国语自产拍| 无码人妻精品一区二区蜜桃网站| 精品一区二区国产在线观看 | 精品国产国语对白久久免费 | 欧美丰满熟妇xxxxx| 天天做天天爱天天要天天| 男人靠女人的免费视频| 色婷婷av久久久久久久| 无码熟熟妇丰满人妻啪啪 | 人妻熟女一区二区aⅴ清水理纱 | 怡红院av一区二区三区|