在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

Recombinant Human Collagen alpha-1 (XXV) chain (COL25A1), partial

  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-YP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-EP866308HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-BP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Collagen alpha-1(XXV) chain(COL25A1),partial
  • 貨號：
    CSB-MP866308HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COL25A1
  • Uniprot No.：
  • 別名：
    COL25A1Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P) [Cleaved into: Collagen-like Alzheimer amyloid plaque component; CLAC)]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
  • 基因功能參考文獻：
    1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence. PMID: 26486031
    2. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder. PMID: 25500261
    3. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia PMID: 23018867
    4. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence. PMID: 22297151
    5. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25 PMID: 21688384
    6. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease PMID: 18501477
    7. COL25A1 leads to Alzheimer's disease-like pathology in vivo PMID: 19548013
    8. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide PMID: 15522881
    9. CLACbinds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils PMID: 15615705
    10. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases. PMID: 15853808
    11. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth PMID: 16300410

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Fibrosis of extraocular muscles, congenital, 5 (CFEOM5)
  • 亞細胞定位：
    Membrane; Single-pass type II membrane protein. Note=After proteolytic cleavage, CLAC is secreted.
  • 組織特異性：
    Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18603

    OMIM: 610004

    KEGG: hsa:84570

    STRING: 9606.ENSP00000382083

    UniGene: Hs.658842



主站蜘蛛池模板： 国产精品毛片va一区二区三区| 18禁午夜宅男成年网站| 亚洲国产精品成人影片久久| 午夜国产成人片在线播放| 亚洲精品久久久久中文字幕二区 | 亚洲精品无码成人片| 国产剧情无码播放在线观看| 国产丝袜视频一区二区三区| 一性一交一口添一摸视频| 国产ae86亚洲福利入口| 无码三级av电影在线观看| 天堂无码人妻精品av一区 | 国产一区二区三区高清在线观看| 黑森林福利视频导航| 中文字幕久久综合伊人| 免费啪视频在线观看视频日本| 国产在线永久视频| 一区二区乱子伦在线播放| 亚洲欧美成人a∨观看| 免费无码黄十八禁网站在线观看 | 国产福利一区二区三区在线视频 | 国产在线拍偷自揄拍无码 | 国产精品嫩草影院永久…| 国产freexxxx性播放麻豆| 亚洲精品乱码久久久久红杏| 国产精品国产午夜免费看福利| 7777久久久国产精品消防器材| 色欲色香天天天综合无码www| 狠狠色噜噜狠狠狠狠888奇禾 | 国产成人精品日本亚洲语音| 中文字幕无码乱人伦| 亚洲日韩在线中文字幕线路2区| 国产成人av无码永久免费一线天| 97爱亚洲综合成人| 夜爽8888视频在线观看| 无码精品国产一区二区免费| 男女爽爽无遮挡午夜视频| 欧美刺激性大交| 欧美成人精精品一区二区| 美女露出粉嫩小奶头在视频18禁| 国产97色在线 | 亚洲|