在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Claudin-8 (CLDN8), partial

  • 中文名稱:
    Recombinant Human Claudin-8(CLDN8),partial
  • 貨號:
    CSB-YP005510HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Claudin-8(CLDN8),partial
  • 貨號:
    CSB-EP005510HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Claudin-8(CLDN8),partial
  • 貨號:
    CSB-EP005510HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Claudin-8(CLDN8),partial
  • 貨號:
    CSB-BP005510HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Claudin-8(CLDN8),partial
  • 貨號:
    CSB-MP005510HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    CLDN8
  • Uniprot No.:
  • 別名:
    CLDN8; UNQ779/PRO1573; Claudin-8
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. the present study revealed the distinct expression profiles of claudin5, 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma PMID: 29901188
    2. data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine PMID: 29145422
    3. these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer PMID: 28474805
    4. Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway. PMID: 27029486
    5. High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma. PMID: 26560196
    6. the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues. PMID: 26464708
    7. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    8. claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma PMID: 18799195
    9. Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon. PMID: 19000657
    10. the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas. PMID: 19302533
    11. CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Expressed in the epididymis, mainly in the caput segment.
  • 數據庫鏈接:

    HGNC: 2050

    OMIM: 611231

    KEGG: hsa:9073

    STRING: 9606.ENSP00000286809

    UniGene: Hs.162209



主站蜘蛛池模板: 国产欧美综合一区二区三区| 成人午夜电影福利免费| 亚洲精品色无码av试看| 国产美女露脸口爆吞精| 一区二区三区乱码在线 | 欧洲| 曰本无码人妻丰满熟妇啪啪| 动漫av网站免费观看| 色五月丁香五月综合五月4438| 天堂在线www中文| 国产美女遭强高潮网站下载| 中文字幕亚韩| 凹凸国产熟女精品视频| 无码专区视频精品老司机| 亚洲国产成人无码电影| 中文字幕无码精品亚洲35| 欧美成人免费全部| 西西人体大胆扒开下部337卩| 久久国产乱子伦精品免费台湾| 97久久精品人人澡人人爽| 亚洲爆乳无码一区二区三区| 亚洲成色最大综合在线| 亚洲 欧美 国产 综合免费| 人人妻人人澡人人爽精品欧美| 国产乱码精品一区二区三区中文 | 又粗又硬整进去好爽视频| 中文字幕精品视频在线看免费 | 精品人妻系列无码专区| 伊人久久精品无码二区麻豆| 欧美日韩欧美| 国产69囗曝吞精在线视频| 国产精品香蕉视频在线| 国产一区二区内射最近更新| 国产精品亚洲一区二区无码| 一本大道无码av天堂| 亚洲日本一区二区三区在线| 亚洲欧洲免费无码| 久久综合色一综合色88| 777米奇色狠狠俺去啦| 国产精品视频| 欧美巨大xxxx做受高清| 欧美成人午夜性视频|