在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLDN8 Antibody

  • 中文名稱:
    CLDN8兔多克隆抗體
  • 貨號:
    CSB-PA104901
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells, using CLDN8 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLDN8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CLDN8
  • 別名:
    CLDN8; UNQ779/PRO1573; Claudin-8
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human CLDN8.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. the present study revealed the distinct expression profiles of claudin5, 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma PMID: 29901188
    2. data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine PMID: 29145422
    3. these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer PMID: 28474805
    4. Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway. PMID: 27029486
    5. High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma. PMID: 26560196
    6. the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues. PMID: 26464708
    7. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    8. claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma PMID: 18799195
    9. Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon. PMID: 19000657
    10. the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas. PMID: 19302533
    11. CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Expressed in the epididymis, mainly in the caput segment.
  • 數據庫鏈接:

    HGNC: 2050

    OMIM: 611231

    KEGG: hsa:9073

    STRING: 9606.ENSP00000286809

    UniGene: Hs.162209



主站蜘蛛池模板: 狠狠色婷婷久久综合频道日韩| 在线看片福利无码网址| av免费网址在线观看| 国产亚洲精品久久久久久久软件| 精品午夜国产福利观看| 女人被狂躁高潮啊的视频在线看| 成人影院yy111111在线观看| 人人妻人人澡人人爽人人精品av | av永久天堂一区| 蜜臀av在线观看| 久久久精品人妻一区亚美研究所| 亚洲精品一区二区丝袜图片| 欧美饥渴少妇xxxxx性| 苍井空一区二区波多野结衣av| 精品无码中文视频在线观看| а√天堂www在线а√天堂视频 | 国产精品青青在线观看爽| 噜噜高清欧美内射短视频| 免费又黄又爽又色的视频| 乱中年女人伦av一区二区| 美女被啪到深处抽搐视频| 国语高潮无遮挡无码免费看| 日韩精品成人av在线观看| 热re99久久精品国99热| 国产成人av综合久久| 国产av一区二区精品凹凸| 亚洲va中文字幕无码久久不卡| 国产精品视频一区二区三区不卡 | 日日碰狠狠丁香久燥| 久久综合久久鬼色| 国产精品一区波多野结衣| 综合 欧美 小说 另类 图| 人妻丰满熟妇岳av无码区hd| 欧美丰满少妇xxxx性| 午夜无码片在线观看影院y| 人妻少妇久久中文字幕| 无码av中文一区二区三区桃花岛| 国产xxxx视频在线| 久久亚洲色www成人不卡| 亚洲成av人无码综合在线观看| 国产精品久久久天天影视|