在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLDN8 Antibody

CLDN8 Antibody

  • 中文名稱：
    CLDN8兔多克隆抗體
  • 貨號：
    CSB-PA042402
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA042402(CLDN8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA042402(CLDN8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLDN8
  • 別名：
    CLDN8; UNQ779/PRO1573; Claudin-8
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human CLDN8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻(xiàn)：
    1. the present study revealed the distinct expression profiles of claudin5, 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma PMID: 29901188
    2. data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine PMID: 29145422
    3. these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer PMID: 28474805
    4. Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway. PMID: 27029486
    5. High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma. PMID: 26560196
    6. the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues. PMID: 26464708
    7. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    8. claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma PMID: 18799195
    9. Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon. PMID: 19000657
    10. the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas. PMID: 19302533
    11. CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the epididymis, mainly in the caput segment.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2050

    OMIM: 611231

    KEGG: hsa:9073

    STRING: 9606.ENSP00000286809

    UniGene: Hs.162209



主站蜘蛛池模板： 国产内射爽爽大片视频社区在线| 天天澡日日澡狠狠欧美老妇| 午夜性色福利在线观看视频| 国产精品_九九99久久精品| 日本动漫瀑乳h动漫啪啪免费| 精品一区二区三区四区五区六区 | 国产私人尤物无码不卡| 午夜福利一区二区三区高清视频| 77se77亚洲欧美在线| 日本xxxx18野外无毒不卡| 亚洲 欧美 激情 小说 另类| 免费人妻精品一区二区三区| 国内精品久久久久影院蜜芽| 国产精品 中文字幕 亚洲 欧美| 正在播放国产乱子伦最新视频| 在线成人一区二区| 另类老妇奶性生bbwbbw| 日本www一道久久久免费| 久久久99精品成人片| 日韩精品射精管理在线观看| 精品少妇人妻av一区二区三区| 久久不见久久见免费影院www日本| 越猛烈欧美xx00动态图| 一区二区三区av高清免费波多| 国产精品亚洲一区二区| 中文字幕在线观看亚洲日韩| 久久天天躁夜夜躁狠狠i女人| 少妇高潮惨叫久久久久电影| 人妻少妇精品久久| 国产精品美女一区二区视频| 久久久久久国产精品美女| 国产午夜理论不卡在线观看| 妺妺窝人体色www看人体| 日韩中文字幕免费视频| 影音先锋人妻av中文字幕久久| 羞涩的丰满人妻40p| 5858s亚洲色大成网站www| 少妇邻居内射在线| 男人边吻奶边挵进去视频| 国产精品9999久久久久| 成人天堂资源www在线|