在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLDN8 Antibody

CLDN8 Antibody

  • 中文名稱：
    CLDN8兔多克隆抗體
  • 貨號：
    CSB-PA042402
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA042402(CLDN8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA042402(CLDN8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLDN8
  • 別名：
    CLDN8; UNQ779/PRO1573; Claudin-8
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human CLDN8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻(xiàn)：
    1. the present study revealed the distinct expression profiles of claudin5, 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore, the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma PMID: 29901188
    2. data support that the tight junction protein claudin 8 exon 1 is a predictor for the plasma levels of IP-10 in MMT patients with urine test positive for morphine PMID: 29145422
    3. these results indicate that CLDN8 functions as an androgen receptordownstream signal to facilitate the progression of prostate cancer PMID: 28474805
    4. Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 pathway. PMID: 27029486
    5. High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma. PMID: 26560196
    6. the expression of claudin-5 and claudin-9 was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues. PMID: 26464708
    7. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    8. claudin-7 and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma and oncocytoma PMID: 18799195
    9. Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon. PMID: 19000657
    10. the combination of CK7, S100A1 and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma or renal oncocytomas. PMID: 19302533
    11. CLDN8, clustered with CLDN17 at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the epididymis, mainly in the caput segment.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2050

    OMIM: 611231

    KEGG: hsa:9073

    STRING: 9606.ENSP00000286809

    UniGene: Hs.162209



主站蜘蛛池模板： 成熟老妇女毛茸茸的做性| 尤物yw午夜国产精品大臿蕉| 欧美亚洲国产手机在线有码| 野花社区免费观看在线www| 人人妻人人澡av| 综合天堂av久久久久久久| 熟妇人妻无码中文字幕老熟妇| 国产粗话肉麻对白在线播放| 成人无码一区二区三区网站| 77777_亚洲午夜久久多人| 成人免费直播| 国产美女爽到喷出水来视频| 日韩欧美国产aⅴ另类| 性色av无码久久一区二区三区 | 日本熟妇色xxxxx欧美老妇| 亚洲精品www久久久| 国产成人精品a视频一区| 久久久久99精品成人片牛牛影视| 女人被躁到高潮免费视频软件 | 天天躁夜夜躁狠狠躁2021| 免费国产在线精品一区二区三区| 成人免费国产精品视频| 亚洲无线观看国产精品| 992tv精品视频tv在线观看| 国产女人乱人伦精品一区二区| 97精品人人a片免费看| 日韩人妻无码制服丝袜视频| 人人澡人人澡人人看添av| 亚洲一区二区三区四区| 日本三级成本人网站| 国产精品亚洲二区在线播放| 午夜无码国产理论在线| 人妻无码久久久久久久久久久| 成人国产网站v片免费观看| 激情文学小说区另类小说同性| 在线观看肉片av网站免费| 欧美大屁股xxxx高跟欧美黑人| 久久精品aⅴ无码中文字字幕不卡| 人妻少妇熟女javhd| 暖暖视频日本在线观看| 国产美女爽到喷出水来视频|