在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Charged multivesicular body protein 4b (CHMP4B)

  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 4b(CHMP4B)
  • 貨號:
    CSB-YP887976HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 4b(CHMP4B)
  • 貨號:
    CSB-EP887976HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 4b(CHMP4B)
  • 貨號:
    CSB-BP887976HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Charged multivesicular body protein 4b(CHMP4B)
  • 貨號:
    CSB-MP887976HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Charged multivesicular body protein 4b; CHM4B_HUMAN; chmp4b; Chromatin-modifying protein 4b; hSnf7-2; hVps32-2; SNF7 homolog associated with Alix 1; SNF7-2; Vacuolar protein sorting-associated protein 32-2; Vps32-2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-224
  • 氨基酸序列
    SVFGKLFGA GGGKAGKGGP TPQEAIQRLR DTEEMLSKKQ EFLEKKIEQE LTAAKKHGTK NKRAALQALK RKKRYEKQLA QIDGTLSTIE FQREALENAN TNTEVLKNMG YAAKAMKAAH DNMDIDKVDE LMQDIADQQE LAEEISTAIS KPVGFGEEFD EDELMAELEE LEQEELDKNL LEISGPETVP LPNVPSIALP SKPAKKKEEE DDDMKELENW AGSM
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan.; (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
  • 基因功能參考文獻:
    1. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1) PMID: 28806752
    2. homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity PMID: 26866605
    3. our results implied that CHMP4B could be a promising prognostic biomarker as well as a potential therapeutic target of HCC. PMID: 25874485
    4. CHMP4B, through its association with chromatin, may participate in the autophagolysosomal degradation of micronuclei and other extranuclear chromatin. PMID: 24741567
    5. hSnf7-1 and hSnf7-2 are preferentially associated with CHMP2A and CHMP2B, respectively, and regulate the turnover of distinct transmembrane cargos such as neurotransmitter receptors in human neurons. PMID: 21975012
    6. CHMP4b and Alix participate in formation of multivesicular bodies by cooperating with SKD1 PMID: 12860994
    7. ALIX can have a dramatic effect on HIV-1 release by binding at the CHMP4B site; the ability to use ALIX may allow HIV-1 to replicate in cells that express only low levels of Tsg101 PMID: 17428861
    8. These data provide the first evidence that CHMP4B plays a vital role the maintenance of lens transparency. PMID: 17701905
    9. Results suggest that efficient interaction between CHMP4s and Brox requires Brox farnesylation. PMID: 18190528
    10. Study demonstrates that CHMP4A and CHMP4B proteins form novel membrane-attached filaments that can promote or stabilize negative curvature and outward budding. PMID: 18209100
    11. The Bro1 domain of ALIX binds specifically to C-terminal residues of the human CHMP4B. PMID: 18511562
    12. The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix. PMID: 19016654

    顯示更多

    收起更多

  • 相關疾病:
    Cataract 31, multiple types (CTRCT31)
  • 亞細胞定位:
    Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein. Midbody. Nucleus envelope.
  • 蛋白家族:
    SNF7 family
  • 組織特異性:
    Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.
  • 數據庫鏈接:

    HGNC: 16171

    OMIM: 605387

    KEGG: hsa:128866

    STRING: 9606.ENSP00000217402

    UniGene: Hs.472471



主站蜘蛛池模板: 一本一道波多野结衣av一区| 国产日韩综合一区在线观看| 日本免费一区二区三区视频观看| 国产女主播白浆在线观看| 538prom精品视频在线播放| 一区二区狠狠色丁香久久婷婷| 成人三级无码视频在线观看| 国产亚洲精品久久久久久牛牛| 777精品出轨人妻国产| 亚洲男人片片在线观看| 亚洲精品gv天堂无码男同| 国产精品久久久影视青草| 久久99精品久久久久婷婷暖| 精品免费国产一区二区| 国产全是老熟女太爽了| 亚洲成av人在线视| 爱色精品视频一区二区| 国产老太睡小伙子视频| 野花社区在线观看视频| 国产日产欧洲无码视频| 上司人妻互换hd无码| 好爽好硬好深高潮视频456| 性猛交ⅹxxx富婆视频| 国产亚洲视频在线播放香蕉| 无码人妻天天拍夜夜爽| 日韩电影一区二区三区| 伊人蕉久中文字幕无码专区 | 乱码丰满人妻一二三区| 亚洲精品国产第一区第二| 极品少妇被猛得白浆直喷白浆小说| 亚洲精品无码久久久| 欧美国产成人精品一区二区三区| 制服 丝袜 亚洲 中文 综合| 2022国产日产欧产精品| 国产麻豆一精品一av一免费| 丝袜高跟麻麻浓精受孕人妻| 亚洲精品无码中文久久字幕| 妺妺窝人体色www在线小说| 成熟老妇女毛茸茸的做性| 嫩草av久久伊人妇女超级a| 免费大黄网站|