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  4. Recombinant Human Cerebral dopamine neurotrophic factor (CDNF)

Recombinant Human Cerebral dopamine neurotrophic factor (CDNF)

  • 中文名稱：
    Recombinant Human Cerebral dopamine neurotrophic factor(CDNF)
  • 貨號：
    CSB-YP676596HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cerebral dopamine neurotrophic factor(CDNF)
  • 貨號：
    CSB-EP676596HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cerebral dopamine neurotrophic factor(CDNF)
  • 貨號：
    CSB-EP676596HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cerebral dopamine neurotrophic factor(CDNF)
  • 貨號：
    CSB-BP676596HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cerebral dopamine neurotrophic factor(CDNF)
  • 貨號：
    CSB-MP676596HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CDNF
  • Uniprot No.：
  • 別名：
    Arginine rich mutated in early stage tumors like 1; ARMET L1; ARMET like protein 1; ARMET-like protein 1; ARMETL 1; ARMETL1; CDNF; CDNF_HUMAN; Cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    25-187
  • 氨基酸序列
    QGQEAG GRPGADCEVC KEFLNRFYKS LIDRGVNFSL DTIEKELISF CLDTKGKENR LCYYLGATKD AATKILSEVT RPMSVHMPAM KICEKLKKLD SQICELKYEK TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA THPKTEL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
  • 基因功能參考文獻：
    1. Polymorphisms in CDN,F identified in a Han Chinese population, were associated with increased susceptibility to schizophrenia. PMID: 29298719
    2. In various animal models of Parkinson Disease, CDNF is efficient in protecting and repairing dopaminergic neurons, and it inhibits endoplasmic reticulum stress, euroinflammation, and apoptosis. PMID: 28337696
    3. The results showed that AAV8-CDNF administration significantly improved the motor function and increased the tyrosine hydroxylase (TH) levels in Parkinson's disease rats with mild lesions (2 weeks post lesion), but it had limited therapeutic effects in rats with severe lesions (5 weeks post lesion). PMID: 28622392
    4. Results suggest that CDNF treatment selectively enhances long-term memory consolidation PMID: 25975173
    5. showed that CDNF was able to protect dopaminergic neurons against injury caused by alpha-synuclein oligomers. This advises its use against physiological damages caused by alpha-synuclein oligomers PMID: 26149686
    6. Expression of CDNF in the substantia nigra has an anti-inflammatory effect on experimental Parkinson's disease. PMID: 25511018
    7. Although no CDNF mutations are found in early-onset Parkinson's disease patient samples, a trend towards increased risk for Parkinson's in carriers of the C allele of rs7094179 single nucleotide polymorphism (SNP) is found. PMID: 21320571
    8. expressed in several tissues; might be beneficial for the treatment of Parkinson's disease PMID: 17611540
    9. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449
    10. Study suggests that there is no association between variants in the CDNF gene and cocaine dependence. PMID: 19429035
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429035

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    ARMET family
  • 組織特異性：
    Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum.
  • 數據庫鏈接：

    HGNC: 24913

    OMIM: 611233

    KEGG: hsa:441549

    STRING: 9606.ENSP00000419395

    UniGene: Hs.559067



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