在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Centromere protein H (CENPH)

Recombinant Human Centromere protein H (CENPH)

  • 中文名稱：
    Recombinant Human Centromere protein H(CENPH)
  • 貨號：
    CSB-YP005211HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Centromere protein H(CENPH)
  • 貨號：
    CSB-EP005211HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Centromere protein H(CENPH)
  • 貨號：
    CSB-BP005211HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Centromere protein H(CENPH)
  • 貨號：
    CSB-MP005211HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CENPH
  • Uniprot No.：
  • 別名：
    CENP H; CENP-H; CENPH; CENPH_HUMAN; Centromere protein H; ICEN35; Interphase centromere complex protein 35; Kinetochore protein CENP H; NNF1; NNF1; MIND kinetochore complex component; homolog; PMF1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-247
  • 氨基酸序列
    MEEQPQMQDA DEPADSGGEG RAGGPPQVAG AQAACSEDRM TLLLRLRAQT KQQLLEYKSM VDASEEKTPE QIMQEKQIEA KIEDLENEIE EVKVAFEIKK LALDRMRLST ALKKNLEKIS RQSSVLMDNM KHLLELNKLI MKSQQESWDL EEKLLDIRKK RLQLKQASES KLLEIQTEKN KQKIDLDSME NSERIKIIRQ NLQMEIKITT VIQHVFQNLI LGSKVNWAED PALKEIVLQL EKNVDMM
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
  • 基因功能參考文獻(xiàn)：
    1. In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression. PMID: 28498417
    2. Upregulation of centromere protein H is associated with progression of renal cell carcinoma PMID: 26248586
    3. propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation PMID: 26378239
    4. CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC. PMID: 23970101
    5. CENP-H promotes the proliferation of human gastric cancer cells PMID: 22381774
    6. High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role. PMID: 22999412
    7. Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage. PMID: 21880184
    8. upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases PMID: 22631655
    9. Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas. PMID: 22682030
    10. CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers. PMID: 15930286
    11. The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres. PMID: 16622420
    12. has an important impact on the architecture and function of the human kinetochore complex PMID: 16875666
    13. CENP-H has a role in preventing progression of nasopharyngeal carcinoma PMID: 17255272
    14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
    15. CENP-H protein has a role in esophageal carcinoma progression PMID: 18700042
    16. expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer PMID: 19170237
    17. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H. PMID: 19232519
    18. Upregulation of CENP-H in tongue cancer is associated with disease progression. PMID: 19500341
    19. CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. PMID: 19625449

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
  • 蛋白家族：
    CENP-H/MCM16 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17268

    OMIM: 605607

    KEGG: hsa:64946

    STRING: 9606.ENSP00000283006

    UniGene: Hs.631967



主站蜘蛛池模板： 国产成人不卡无码免费视频| 国产女主播白浆在线观看| 亚洲综合国产一区二区三区| 国产免费无码一区二区视频| 忘忧草社区中文字幕www| 久久久久欧美国产高潮| 成人免费视频在线观看地区免下载| 青椒国产97在线熟女| 久久精品日韩av无码| 好了av四色综合无码| 久久精品国产精品青草| 粗大的内捧猛烈进出少妇视频| 成在线人免费视频播放| 欧美日韩中文国产一区发布| 国模无码视频一区| 国产精品亚洲欧美大片在线观看| 亚洲kkk4444在线观看| 欧美亚洲日韩不卡在线在线观看| 韩国三级中文字幕hd| 日本乱子人伦在线视频| 国产成人免费97在线观看| 国产亚洲aⅴ在线电影| 午夜精品影视国产一区在线麻豆 | 美乳丰满人妻无码视频| 免费人成网站在线视频| 少妇性荡欲午夜性开放视频剧场| 刺激一区仑乱| 人妻久久久精品99系列2021| 亚洲综合精品香蕉久久网| 玩弄少妇人妻中文字幕| 无码国产精品一区二区高潮| 国产suv精品一区二区883| 欧洲极品无码一区二区三区 | 国产免费无遮挡吸奶头视频 | 欧洲熟妇色xxxxx欧美| 欧精国精产品一区| 97久久超碰国产精品2021| 久久97国产超碰青草| 成人h无码动漫超w网站| 免费网站观看www在线观看 | 亚洲国产av一区二区三区|