在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CENPH Antibody

  • 中文名稱:
    CENPH兔多克隆抗體
  • 貨號:
    CSB-PA005211GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CENPH
  • 別名:
    CENP H antibody; CENP-H antibody; CENPH antibody; CENPH_HUMAN antibody; Centromere protein H antibody; ICEN35 antibody; Interphase centromere complex protein 35 antibody; Kinetochore protein CENP H antibody; NNF1 antibody; NNF1; MIND kinetochore complex component; homolog antibody; PMF1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CENPH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
  • 基因功能參考文獻:
    1. In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression. PMID: 28498417
    2. Upregulation of centromere protein H is associated with progression of renal cell carcinoma PMID: 26248586
    3. propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation PMID: 26378239
    4. CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC. PMID: 23970101
    5. CENP-H promotes the proliferation of human gastric cancer cells PMID: 22381774
    6. High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role. PMID: 22999412
    7. Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage. PMID: 21880184
    8. upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases PMID: 22631655
    9. Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas. PMID: 22682030
    10. CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers. PMID: 15930286
    11. The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres. PMID: 16622420
    12. has an important impact on the architecture and function of the human kinetochore complex PMID: 16875666
    13. CENP-H has a role in preventing progression of nasopharyngeal carcinoma PMID: 17255272
    14. CENP-C and CENP-H co-localize to the CENP-A chromatin domain. PMID: 17651496
    15. CENP-H protein has a role in esophageal carcinoma progression PMID: 18700042
    16. expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer PMID: 19170237
    17. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H. PMID: 19232519
    18. Upregulation of CENP-H in tongue cancer is associated with disease progression. PMID: 19500341
    19. CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. PMID: 19625449

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
  • 蛋白家族:
    CENP-H/MCM16 family
  • 數據庫鏈接:

    HGNC: 17268

    OMIM: 605607

    KEGG: hsa:64946

    STRING: 9606.ENSP00000283006

    UniGene: Hs.631967



主站蜘蛛池模板: 国产午夜福利精品久久2021| 中文字字幕乱码视频高清| 玩弄放荡人妻少妇系列| 国产精品日韩欧美一区二区三区| 9l国产精品久久久久尤物| 中文在线а天堂| 国产亚洲精品国产福利你懂的| 亚洲综合色无码| 国产sm调教折磨视频| 亚洲人成电影网站色| 色伦专区97中文字幕| 777米奇色狠狠888俺也去乱| 疯狂撞击丝袜人妻| 亚洲偷自拍国综合色帝国| 日本高清不卡aⅴ免费网站| 亚洲精品久久久久国产| 久久人人爽人人爽人人片| 久久精品成人免费观看三| 在线天堂免费观看.www| 亚洲精品欧美二区三区中文字幕| 久久久久国产一区二区三区| 亚洲成a人片在线播放| 亚洲欧洲日产国码无码| 成年美女黄网站色奶头大全| 欧美一区二区三区视频在线观看| 男女无遮挡猛进猛出免费观看视频| 男人靠女人的免费视频| 精品一区二区三区无码视频| 精品欧美h无遮挡在线看中文| yyyy11111少妇影院| 曰本女人牲交高潮视频| 亚洲色欲综合一区二区三区 | 综合无码成人aⅴ视频在线观看| 国产欧美另类久久久精品不卡| 国产亚av手机在线观看| 男人添女人下部高潮视频| 亚洲国产综合在线观看不卡| av小次郎收藏| 亚州少妇无套内射激情视频| 国产在线一区二区在线视频 | 无码国产精品一区二区免费模式|