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  4. Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), partial

Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), partial

  • 中文名稱：
    人MICU1重組蛋白
  • 貨號：
    CSB-YP860652HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MICU1重組蛋白
  • 貨號：
    CSB-EP860652HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MICU1重組蛋白
  • 貨號：
    CSB-EP860652HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MICU1重組蛋白
  • 貨號：
    CSB-BP860652HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MICU1重組蛋白
  • 貨號：
    CSB-MP860652HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Allergen Hom s 4; ara CALC; atopy related autoantigen ; atopy related autoantigen CALC ; Atopy-related autoantigen CALC; CALC; calcium binding atopy related autoantigen 1; Calcium uptake protein 1; calcium uptake protein 1, mitochondrial ; Calcium-binding atopy-related autoantigen 1; CBARA1; EFHA3; FLJ12684; MICU1; MICU1_HUMAN; mitochondrial; mitochondrial calcium uptake 1 ; MPXPS
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
  • 基因功能參考文獻：
    1. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
    2. drives aberrant metabolism that fuels aerobic glycolysis and chemoresistance in ovarian cancer PMID: 28530221
    3. the absence of MICU1, both Mn(2+) and Ca(2+) can pass through the uniporter, as evidenced by mitochondrial Mn(2+) uptake assays, mitochondrial membrane potential measurements, and mitoplast electrophysiology. PMID: 30082385
    4. Mitochondrial Ca(2+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2+) sensitivity. UCP2/3 normalize Ca(2+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2+) uptake activity. PMID: 27642082
    5. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
    6. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
    7. MICU1 serves as a signal-noise discriminator in mitochondrial calcium signalling, limiting the energetic costs of mitochondrial Ca2+ signalling which may undermine oxidative phosphorylation, especially in tissues with highly dynamic energetic demands. PMID: 28132899
    8. Results showed that the SNP on EF-hand Ca2+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients PMID: 27297032
    9. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells. PMID: 26489515
    10. Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression. PMID: 26336993
    11. Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer. PMID: 25824785
    12. Expression of MICU1 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
    13. MICU1 EF hands determine MCU activity, but not binding. PMID: 24332854
    14. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
    15. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. PMID: 24336167
    16. Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2+) overload. PMID: 23747253
    17. CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation. PMID: 23667653
    18. MICU1 is a novel regulator of the machinery in cancer cells that prevents apoptosis. PMID: 23615904
    19. MICU1 is a gatekeeper of mitochondrial calcium uniporter-mediated Ca(2 )uptake that is essential to prevent [Ca(2 )]overload and associated stress. PMID: 23101630
    20. the crucial role of MICU1 and MCU in mitochondrial Ca(2+) uptake in pancreatic beta-cells and their involvement in the positive feedback required for sustained insulin secretion. PMID: 22904319
    21. MICU1 physically interacts with MCU, a principal component of the mitochondrial calcium uniporter. PMID: 21685886
    22. MICU1 represents the founding member of a set of proteins required for high-capacity mitochondrial calcium uptake PMID: 20693986
    23. MICU1 (CBARA1) is an EF-hand containing protein associated with the mitochondrial inner membrane. It is required for mitochondrial calcium uptake in HeLa cells. PMID: 20693986

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  • 相關疾病：
    Myopathy with extrapyramidal signs (MPXPS)
  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
  • 蛋白家族：
    MICU1 family, MICU1 subfamily
  • 組織特異性：
    Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
  • 數據庫鏈接：

    HGNC: 1530

    OMIM: 605084

    KEGG: hsa:10367

    STRING: 9606.ENSP00000354415

    UniGene: Hs.524367



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