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MICU1 Antibody, HRP conjugated

  • 中文名稱:
    MICU1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA860652LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MICU1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Allergen Hom s 4 antibody; ara CALC antibody; atopy related autoantigen antibody; atopy related autoantigen CALC antibody; Atopy-related autoantigen CALC antibody; CALC antibody; calcium binding atopy related autoantigen 1 antibody; Calcium uptake protein 1 antibody; calcium uptake protein 1, mitochondrial antibody; Calcium-binding atopy-related autoantigen 1 antibody; CBARA1 antibody; EFHA3 antibody; FLJ12684 antibody; MICU1 antibody; MICU1_HUMAN antibody; mitochondrial antibody; mitochondrial calcium uptake 1 antibody; MPXPS antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
  • 基因功能參考文獻:
    1. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
    2. drives aberrant metabolism that fuels aerobic glycolysis and chemoresistance in ovarian cancer PMID: 28530221
    3. the absence of MICU1, both Mn(2+) and Ca(2+) can pass through the uniporter, as evidenced by mitochondrial Mn(2+) uptake assays, mitochondrial membrane potential measurements, and mitoplast electrophysiology. PMID: 30082385
    4. Mitochondrial Ca(2+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2+) sensitivity. UCP2/3 normalize Ca(2+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2+) uptake activity. PMID: 27642082
    5. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
    6. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
    7. MICU1 serves as a signal-noise discriminator in mitochondrial calcium signalling, limiting the energetic costs of mitochondrial Ca2+ signalling which may undermine oxidative phosphorylation, especially in tissues with highly dynamic energetic demands. PMID: 28132899
    8. Results showed that the SNP on EF-hand Ca2+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients PMID: 27297032
    9. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells. PMID: 26489515
    10. Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression. PMID: 26336993
    11. Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer. PMID: 25824785
    12. Expression of MICU1 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
    13. MICU1 EF hands determine MCU activity, but not binding. PMID: 24332854
    14. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
    15. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. PMID: 24336167
    16. Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2+) overload. PMID: 23747253
    17. CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation. PMID: 23667653
    18. MICU1 is a novel regulator of the machinery in cancer cells that prevents apoptosis. PMID: 23615904
    19. MICU1 is a gatekeeper of mitochondrial calcium uniporter-mediated Ca(2 )uptake that is essential to prevent [Ca(2 )]overload and associated stress. PMID: 23101630
    20. the crucial role of MICU1 and MCU in mitochondrial Ca(2+) uptake in pancreatic beta-cells and their involvement in the positive feedback required for sustained insulin secretion. PMID: 22904319
    21. MICU1 physically interacts with MCU, a principal component of the mitochondrial calcium uniporter. PMID: 21685886
    22. MICU1 represents the founding member of a set of proteins required for high-capacity mitochondrial calcium uptake PMID: 20693986
    23. MICU1 (CBARA1) is an EF-hand containing protein associated with the mitochondrial inner membrane. It is required for mitochondrial calcium uptake in HeLa cells. PMID: 20693986

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  • 相關疾病:
    Myopathy with extrapyramidal signs (MPXPS)
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
  • 蛋白家族:
    MICU1 family, MICU1 subfamily
  • 組織特異性:
    Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
  • 數據庫鏈接:

    HGNC: 1530

    OMIM: 605084

    KEGG: hsa:10367

    STRING: 9606.ENSP00000354415

    UniGene: Hs.524367



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