在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Calcium-binding protein p22 (CHP)

Recombinant Human Calcium-binding protein p22 (CHP)

  • 中文名稱：
    Recombinant Human Calcium-binding protein p22(CHP)
  • 貨號：
    CSB-YP860773HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-binding protein p22(CHP)
  • 貨號：
    CSB-EP860773HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-binding protein p22(CHP)
  • 貨號：
    CSB-EP860773HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-binding protein p22(CHP)
  • 貨號：
    CSB-BP860773HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-binding protein p22(CHP)
  • 貨號：
    CSB-MP860773HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CHP1
  • Uniprot No.：
  • 別名：
    Calcineurin B homolog; Calcineurin B homologous protein; Calcineurin homologous protein; Calcineurin like EF hand protein 1; Calcium binding protein CHP; Calcium binding protein p22; Calcium-binding protein CHP; Calcium-binding protein p22; chp; CHP1_HUMAN; Sid 470; Sid470; SLC9A1 binding protein; SLC9A1BP; Wrch2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-195
  • 氨基酸序列
    GSRASTLLR DEELEEIKKE TGFSHSQITR LYSRFTSLDK GENGTLSRED FQRIPELAIN PLGDRIINAF FPEGEDQVNF RGFMRTLAHF RPIEDNEKSK DVNGPEPLNS RSNKLHFAFR LYDLDKDEKI SRDELLQVLR MMVGVNISDE QLGSIADRTI QEADQDGDSA ISFTEFVKVL EKVDVEQKMS IRFLH
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells PMID: 12226101
    2. CHP is important for pH(i)-dependent regulation of Na+/H+ exchanger 1 (NHE1) via tightly bound Ca2+ ions which serve as a crucial structural elements required for this role. PMID: 15035633
    3. crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1 PMID: 16511206
    4. helix formation of the cytoplasmic region of NHE1 by calcineurin B homologous protein 1 is a prerequisite for generating the active form of NHE1 PMID: 17050540
    5. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid-anchor.
  • 蛋白家族：
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性：
    Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17433

    OMIM: 606988

    KEGG: hsa:11261

    STRING: 9606.ENSP00000335632

    UniGene: Hs.406234



主站蜘蛛池模板： 亚洲区欧美区综合区自拍区| 久久丫精品久久丫| 中文字幕无码不卡一区二区三区| 国产亚洲视频在线播放香蕉| 色播在线精品一区二区三区四区| 国产专区免费资源网站| 久久久久九九精品影院| 无码专区3d动漫精品免费| 国产卡二卡三卡四卡免费网址 | 中文字幕av免费专区| 97精品人妻系列无码人妻| 国产农村妇女毛片精品久久| 国产日韩欧美亚欧在线| 88久久精品无码一区二区毛片| 国产做爰又粗又大又爽动漫| 国产精品一区二区av交换| 无码少妇一区二区性色av| 亚洲成av人综合在线观看| 国产成人综合色视频精品| 少妇被粗大的猛烈进出动视频| 国产欧美va天堂在线观看视频下载 | 亚洲国产精品综合久久网络| 精品自拍亚洲一区在线| 欧美伦费免费全部午夜最新| 国产成人精品一区二区三区无码| 乱人伦中文字幕成人网站在线| 男人用嘴添女人私密视频| 国产一区二区三区自产| 伊人久久大香线蕉综合中文字幕| 国产成人免费无码视频在线观看| 国产乱码免费卡1卡二卡3| 亚洲精品久久久久中文字幕一福利| 五月天中文字幕mv在线| 国产熟妇搡bbbb搡bbbb搡| 动漫av永久无码精品每日更新| 天堂av成年av影视| 日本免费一区二区三区中文字幕| 人妻少妇邻居少妇好多水在线| 开心色怡人综合网站| 久久久精品免费| 亚洲乱码国产乱码精品精大量|