在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHP1 Antibody

  • 中文名稱:
    CHP1兔多克隆抗體
  • 貨號(hào):
    CSB-PA076309
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, using CHP antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CHP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CHP1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human CHP.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
  • 基因功能參考文獻(xiàn):
    1. serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells PMID: 12226101
    2. CHP is important for pH(i)-dependent regulation of Na+/H+ exchanger 1 (NHE1) via tightly bound Ca2+ ions which serve as a crucial structural elements required for this role. PMID: 15035633
    3. crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1 PMID: 16511206
    4. helix formation of the cytoplasmic region of NHE1 by calcineurin B homologous protein 1 is a prerequisite for generating the active form of NHE1 PMID: 17050540
    5. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid-anchor.
  • 蛋白家族:
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性:
    Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17433

    OMIM: 606988

    KEGG: hsa:11261

    STRING: 9606.ENSP00000335632

    UniGene: Hs.406234



主站蜘蛛池模板: 中文字幕日本最新乱码视频| 国内精品人妻无码久久久影院蜜桃 | 夜夜爽夜夜叫夜夜高潮漏水| 亚洲综合日韩久久成人av| 欧美不卡视频一区发布| 人妻丰满熟妇av无码区| 亚洲中文字幕无码爆乳app| 182tv午夜福利在线地址二| 精品国际久久久久999波多野 | 人妻丰满av无码中文字幕| av东京热无码专区| 巨胸美乳无码人妻视频| 伦理片午夜视频在线观看| 亚州日本乱码一区二区三区| 日本中文字幕在线| 欧美亚洲精品中文字幕乱码| 亚洲精品国产自在现线看| 久久久久亚洲精品成人网| a片免费视频在线观看| 国产亚洲日韩在线播放更多| 亚洲精品tv久久久久久久久j| 亚洲va韩国va欧美va| 人人妻人人爽人人做夜欢视频 | 国产精品成人久久久久久久| 国产做a爱免费视频在线观看 | 夜夜添无码一区二区三区| 国产综合精品| 免费两性的视频网站| 好紧好湿好黄的视频| 欧美亚洲国产精品久久高清 | 996久久国产精品线观看| 蜜桃av亚洲精品一区二区| 精品日产一卡2卡三卡4卡在线| 亚洲国产精品久久久久秋霞影院| 亚洲 另类 日韩 制服 无码| 国产免费二卡3卡四卡| 久久久久九九精品影院| 国产麻豆乱子伦午夜视频观看| 亚洲sm另类一区二区三区| 国产真人性做爰久久网站| 秋霞特色aa大片|