在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHP1 Antibody

  • 中文名稱:
    CHP1兔多克隆抗體
  • 貨號:
    CSB-PA860773LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Rat kidney tissue, Mouse brain tissue
      All lanes: CHP1 antibody at 2.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 23 kDa
      Observed band size: 23 kDa
    • IHC image of CSB-PA860773LA01HU diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescent analysis of Hela cells using CSB-PA860773LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CHP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CHP1
  • 別名:
    Calcineurin B homolog antibody; Calcineurin B homologous protein antibody; Calcineurin homologous protein antibody; Calcineurin like EF hand protein 1 antibody; Calcium binding protein CHP antibody; Calcium binding protein p22 antibody; Calcium-binding protein CHP antibody; Calcium-binding protein p22 antibody; chp antibody; CHP1_HUMAN antibody; Sid 470 antibody; Sid470 antibody; SLC9A1 binding protein antibody; SLC9A1BP antibody; Wrch2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Calcineurin B homologous protein 1 protein (2-195AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,CHP1 Antibody (CSB-PA860773LA01HU),的標記方式是Non-conjugated。對于CHP1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA860773LB01HU CHP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA860773LC01HU CHP1 Antibody, FITC conjugated
    Biotin CSB-PA860773LD01HU CHP1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
  • 基因功能參考文獻:
    1. serum-independent activation of NHE1 by bound CHP2 is one of the key mechanisms for the maintenance of high pH(i) and the resistance to serum deprivation-induced cell death in malignantly transformed cells PMID: 12226101
    2. CHP is important for pH(i)-dependent regulation of Na+/H+ exchanger 1 (NHE1) via tightly bound Ca2+ ions which serve as a crucial structural elements required for this role. PMID: 15035633
    3. crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1 PMID: 16511206
    4. helix formation of the cytoplasmic region of NHE1 by calcineurin B homologous protein 1 is a prerequisite for generating the active form of NHE1 PMID: 17050540
    5. CHP2 has a role in tumorigenesis and as an activator of the calcineurin/NFAT signaling pathway PMID: 18815128

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid-anchor.
  • 蛋白家族:
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性:
    Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17433

    OMIM: 606988

    KEGG: hsa:11261

    STRING: 9606.ENSP00000335632

    UniGene: Hs.406234



主站蜘蛛池模板: 欧美国产日韩a在线视频下载| 综合图区亚洲另类偷窥| 香港经典a毛片免费观看hd | 国产人成视频在线视频| 四虎永久免费地址入口| 精品国产乱码久久久软件下载| 亚洲 欧美 日韩 综合aⅴ视频| 麻豆av福利av久久av| 伊人亚洲综合影院首页| av天堂久久精品影音先锋| 午夜无码人妻av大片色欲| 久久精品中文字幕无码绿巨人| 猫咪www免费人成网站无码| 国产 成人 综合 亚洲 网站| 最近日本免费观看高清视频| 最新亚洲春色av无码专区| 国产在线不卡视频免费视频| 亚洲人成小说网站色在线观看| 精品久久久无码中文字幕| 日本欧美大码a在线观看| 无码成人片在线播放| 亚洲综合激情七月婷婷| 天天躁日日躁狠狠躁av麻豆| 中国熟妇牲交视频| 欧美精品黑人粗大破除 | 色婷婷综合久久久中文字幕| 色五月丁香五月综合五月4438| 亚洲日韩色在线影院性色| 成人免费无码大片a毛片抽搐| 久久午夜福利无码1000合集| 中文国产乱码在线人妻一区二区| 国产婷婷丁香五月缴情成人网| 亚洲国产精品久久久久婷婷老年 | 人妻丰满av无码中文字幕| 青青草大香焦在线综合视频| 久久亚洲精品成人av无码网站| 337p日本欧洲亚洲大胆艺术图| 性饥渴的农村熟妇| 中文字幕在线观看亚洲日韩| 国产成人最新三级在线视频| 国产又爽又大又黄a片|