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  4. Recombinant Human Calcium-activated chloride channel regulator 2 (CLCA2), partial

Recombinant Human Calcium-activated chloride channel regulator 2 (CLCA2), partial

  • 中文名稱：
    Recombinant Human Calcium-activated chloride channel regulator 2(CLCA2) ,partial
  • 貨號：
    CSB-YP890782HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-activated chloride channel regulator 2(CLCA2) ,partial
  • 貨號：
    CSB-EP890782HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-activated chloride channel regulator 2(CLCA2) ,partial
  • 貨號：
    CSB-EP890782HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-activated chloride channel regulator 2(CLCA2) ,partial
  • 貨號：
    CSB-BP890782HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Calcium-activated chloride channel regulator 2(CLCA2) ,partial
  • 貨號：
    CSB-MP890782HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLCA2
  • Uniprot No.：
  • 別名：
    CLCA2; CACC3Calcium-activated chloride channel regulator 2; EC 3.4.-.-; Calcium-activated chloride channel family member 2; hCLCA2; Calcium-activated chloride channel protein 3; CaCC-3; hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2; 109 kDa form; Calcium-activated chloride channel regulator 2; 35 kDa form]
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.
  • 基因功能參考文獻：
    1. we found by calcium imaging that CLCA2 moderately enhanced intracellular-store release but dramatically increased store-operated entry of calcium upon cytosolic depletion PMID: 29758025
    2. CLCA2 links junctional adhesion molecule EVA1, to cytosolic signaling proteins that modulate proliferation and differentiation. PMID: 26930581
    3. CLCA2 expression is higher in squamous cell carcinoma of the lung compared with adenocarcinoma. PMID: 25548429
    4. Variants in CLCA2 were associated with an ileal involvement phenotype of Crohn's disease. PMID: 25557950
    5. These results strongly suggest that CLCA2 is involved in the p53 tumor suppressor network and has a significant effect on cell migration and invasion. PMID: 22990203
    6. hCLCA2 is required for epithelial differentiation, and its loss during tumor progression contributes to metastasis. PMID: 21909135
    7. the reduced expression of CLCA2 was frequently observed in various kinds of cancers including prostate cancer PMID: 22431922
    8. Expression of hSK4 as well as hCACC-2 and hCACC-3 but not hCACC-1 was demonstrated by reverse transcriptase PCR on native nasal tissues. PMID: 12612194
    9. immunohistochemistry clearly demonstrated colocalisation between hCLCA2 and integrin beta4 PMID: 15707651
    10. human CLCA2 protein and mRNA expression are elevated during epithelial stratification, suggesting that this protein plays a role in the growth of multi-layered corneal epithelia during both natural development and tissue cultivation. PMID: 16158324
    11. Mostly extracellular with only a single transmembrane segment, unlikely to form a channel. PMID: 16873362
    12. hCLCA2 Is a p53-Inducible Inhibitor of Breast Cancer Cell Proliferation. PMID: 19654313

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
  • 蛋白家族：
    CLCR family
  • 組織特異性：
    Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenita
  • 數據庫鏈接：

    HGNC: 2016

    OMIM: 604003

    KEGG: hsa:9635

    STRING: 9606.ENSP00000359596

    UniGene: Hs.241551



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