在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human COP9 signalosome complex subunit 8 (COPS8)

Recombinant Human COP9 signalosome complex subunit 8 (COPS8)

  • 中文名稱：
    Recombinant Human COP9 signalosome complex subunit 8(COPS8)
  • 貨號：
    CSB-YP860346HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human COP9 signalosome complex subunit 8(COPS8)
  • 貨號：
    CSB-EP860346HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human COP9 signalosome complex subunit 8(COPS8)
  • 貨號：
    CSB-EP860346HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human COP9 signalosome complex subunit 8(COPS8)
  • 貨號：
    CSB-BP860346HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human COP9 signalosome complex subunit 8(COPS8)
  • 貨號：
    CSB-MP860346HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    COPS8
  • Uniprot No.：
  • 別名：
    COP9 homolog; COP9 signalosome complex subunit 8; COP9 signalosome subunit 8; Cops8; CSN8; CSN8_HUMAN; hCOP9; JAB1 containing signalosome subunit 8; JAB1-containing signalosome subunit 8; SGN8; Signalosome subunit 8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    2-209
  • 氨基酸序列
    PVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713



主站蜘蛛池模板： 国产成人最新三级在线视频| 蜜桃少妇av久久久久久久| 日韩精品亚洲色大成网站| 在线观看精品视频网站| 人人爽人人爽人人片av亚洲| 国产精品熟妇一区二区三区四区| 日日碰狠狠躁久久躁综合小说| 玩弄japan白嫩少妇hd| 丰满少妇作爱视频免费观看 | 无码日韩精品一区二区人妻| 国产另类ts人妖一区二区| 永久黄网站免费视频性色 | 人妻性奴波多野结衣无码| 日韩免费无码专区精品观看| 欧美极品少妇×xxxbbb| 国产av无码久久精品| 日韩插啊免费视频在线观看| 小12萝裸体自慰出白浆| 男女做爰无遮挡性视频| 国产精品自在拍在线拍| 无码人妻啪啪一区二区| 天天躁日日躁狠狠久久| 国产无遮挡又黄又爽奶头| 99久久人妻精品免费一区| 久人人爽人人爽人人片av| 久久综合激激的五月天| 人人爽人人爽人人片av免费| 亚洲午夜精品a片一区二区app| 久久精品国产精品国产精品污| 性欧美大胆免费播放| 狠狠色丁香婷婷综合潮喷| 日韩一卡二卡三卡四卡免费观在线 | 国产熟妇搡bbbb搡bbbb| 国产在线 | 欧洲| 天天摸天天做天天爽天天弄| 美国一区二区三区无码视频| 亚洲国产精品成人午夜在线观看| 高潮毛片无遮挡高清视频播放| 亚洲国产精品日本无码网站| 亚洲va中文字幕无码一二三区| 在线成人www免费观看视频|