在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COPS8 Antibody, HRP conjugated

COPS8 Antibody, HRP conjugated

  • 中文名稱：
    COPS8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA860346LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) COPS8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COPS8
  • 別名：
    COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_HUMAN antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 數據庫鏈接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713



主站蜘蛛池模板： 日韩亚洲欧美中文在线| 精品国产一区二区三区色欲| 中文字幕亚洲无线码一区女同| 精品国产黑色丝袜高跟鞋| 亚洲人成无码网www电影麻豆| 国产高潮又爽又刺激的视频| 欧美老肥熟妇多毛xxxxx| 成人无遮挡裸免费视频在线观看| 国产一区二区三区无码免费| а天堂中文在线官网| 国产成人精品无码片区在线观看| 乱码午夜-极国产极内射| 蜜芽av无码精品国产午夜| www.一区二区三区在线 | 欧洲| 日韩a片无码毛片免费看| 欧美人与动性xxxxx杂| 亚洲性无码av中文字幕| 国产aⅴ爽av久久久久久| 国产成人18黄网站| 揉着我的奶从后面进去视频| 精品夜夜爽欧美毛片视频| 国语精品福利自产拍在线观看 | 国产精品美女久久久久久福利| 亚洲精品久久午夜麻豆| 天天躁日日躁狠狠躁av中文| 女人18片毛片60分钟| 秋霞午夜久久午夜精品| 亚洲欧洲精品a片久久99| 丰满少妇在线观看网站| 成人免费无码av| 精品乱码久久久久久中文字幕| 国产天美传媒性色av出轨| 最近日本精品一卡2卡3卡4卡 | 中国极品少妇xxxxx| 国产无套乱子伦精彩是白视频| 欧美成aⅴ人高清怡红院| 中文字幕亚洲码在线| 国产免费久久精品99久久| 成人h动漫精品一区二区| 天天综合网亚在线| 日韩欧美亚洲综合久久影院|