在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COPS8 Antibody, HRP conjugated

COPS8 Antibody, HRP conjugated

  • 中文名稱：
    COPS8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA860346LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) COPS8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COPS8
  • 別名：
    COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_HUMAN antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 數據庫鏈接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713



主站蜘蛛池模板： 国语少妇高潮对白在线| 欧美人妻aⅴ中文字幕| 国产一区二区女内射| 色妞精品av一区二区三区| 97国语精品自产拍在线观看| 人妻丰满熟妇a无码区| 国产农村妇女高潮大叫| 欧美顶级少妇做爰hd| 天躁夜夜躁狼狠躁| 在线观看的网站| 极品无码av国模在线观看| 99大香伊乱码一区二区| 久久不见久久见免费影院www | 国产美女在线精品免费观看| 亚洲国产成人久久综合人| 成人自慰女黄网站免费大全| 国产无遮挡a片无码免费软件| 国产97色在线 | 亚洲| 亚洲日韩激情无码一区| 亚洲 欧美 另类 综合 日韩| 国内精品久久久久影院亚瑟| 精品少妇无码av无码专区| 一本一道av无码中文字幕| 无码少妇高潮浪潮av久久| 男女啪啪永久免费网站| 色丁香婷婷综合久久| 国产成人无码va在线观看| 好男人在在线社区www在线影院| 国产男女猛烈无遮挡免费视频网站| 女人喷液抽搐高潮视频| 在线观看日本亚洲一区| 成人无码一区二区三区网站| 亚洲精品一线二线三线无人区| 特级无码毛片免费视频尤物| 天堂在线www资源在线| 免费观看成人欧美www色| 国产伦精品一区二区三区免费迷 | 97se亚洲国产综合自在线观看| 极品无码av国模在线观看| 国产精品免费无码二区| 亚洲人成电影在线观看影院|