在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COPS8 Antibody, HRP conjugated

COPS8 Antibody, HRP conjugated

  • 中文名稱：
    COPS8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA860346LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) COPS8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COPS8
  • 別名：
    COP9 homolog antibody; COP9 signalosome complex subunit 8 antibody; COP9 signalosome subunit 8 antibody; Cops8 antibody; CSN8 antibody; CSN8_HUMAN antibody; hCOP9 antibody; JAB1 containing signalosome subunit 8 antibody; JAB1-containing signalosome subunit 8 antibody; SGN8 antibody; Signalosome subunit 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻：
    1. Among 479 individuals affected with clear cell renal cell carcinoma, only synonymous variants were found in COPS8 and one of the missense variants in ACKR3:c.892C>T, was observed in 4/479 individuals screened PMID: 28063109
    2. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 impaired proliferation in HeLa cells. PMID: 23689509
    3. miR-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 and COPS8, inhibiting GPCR-mediated activation of NF-kappaB. PMID: 22992343
    4. proteomic-based approach can broaden our understanding of the functions of the CSN in contexts such as viral-host interactions or immune activation in their natural milieu PMID: 22414063
    5. analysis of the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 PMID: 20399188
    6. DDB2 and CSA are each integrated into nearly identical complexes via interaction with DDB1. Both complexes contain cullin 4A and Roc1 and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN) PMID: 12732143
    7. The COP9 signalosome (CSN) controls NF-kappaB by deubiquitinylation of IkappaBalpha. PMID: 17318178
    8. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination PMID: 18424433

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN8 family
  • 數據庫鏈接：

    HGNC: 24335

    OMIM: 616011

    KEGG: hsa:10920

    STRING: 9606.ENSP00000346340

    UniGene: Hs.531713



主站蜘蛛池模板： 色婷婷六月亚洲综合香蕉| 欧美熟妇乱子伦xx视频| 97精品尹人久久大香线蕉| 日韩精品成人一区二区三区| 4hu四虎永久免费地址ww416| 亚洲国产成人久久综合三区| 国产在线无码播放不卡视频| 人妻在线无码一区二区三区| 狠狠cao日日穞夜夜穞av| 亚洲深深色噜噜狠狠爱网站 | 人人爽人人爽人人片av亚洲 | 丁香五月开心婷婷激情综合| 中国老妇xxxx性开放| 欧美国产一区二区三区激情无套 | 亚洲日韩欧美国产高清αv| 人妻在客厅被c的呻吟| 亚洲欧美人成网站aaa| 无码潮喷a片无码高潮视频| 天天综合网网欲色| 99久久精品免费看国产一区二区| 国产+成+人+亚洲欧洲自线| 老司机在线精品视频播放| 婷婷四房综合激情五月| 日韩精品无码免费专区午夜不卡 | 国产精品186在线观看在线播放| 免费国产白丝喷水娇喘视频| 又粗又黄又猛又爽大片免费| 国产成_人_综合_亚洲_国产| 无套内内射视频网站| www亚洲精品久久久| 内射一区二区精品视频在线观看| 人与性动交aaaabbbb| 成人精品一区二区三区中文字幕| 亚洲狠狠色成人综合网| 国产欧美日韩精品专区| 亚洲春色在线视频| 熟妇人妻无码xxx视频| 国产av麻豆天堂亚洲国产av刚刚碰| 国产乱人伦中文无无码视频试看| 欧美日韩一区二区成人午夜电影 | 一本色综合亚洲精品蜜桃冫|