在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human COP9 signalosome complex subunit 3 (COPS3)

  • 中文名稱:
    Recombinant Human COP9 signalosome complex subunit 3(COPS3)
  • 貨號:
    CSB-YP892483HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human COP9 signalosome complex subunit 3(COPS3)
  • 貨號:
    CSB-EP892483HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human COP9 signalosome complex subunit 3(COPS3)
  • 貨號:
    CSB-EP892483HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human COP9 signalosome complex subunit 3(COPS3)
  • 貨號:
    CSB-BP892483HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human COP9 signalosome complex subunit 3(COPS3)
  • 貨號:
    CSB-MP892483HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    COPS3
  • Uniprot No.:
  • 別名:
    Constitutive photomorphogenic homolog subunit 3; COP 9 (constitutive photomorphogenic) subunit 3; COP 9 complex homolog subunit 3; COP 9 complex S3; COP 9 complex subunit 3; COP 9 constitutive photomorphogenic homolog subunit 3; COP 9 homolog; COP 9 signalosome complex subunit 3; COP 9 signalosome subunit 3; COP 9 subunit 3; COP9 (constitutive photomorphogenic) subunit 3; COP9 complex homolog subunit 3; COP9 complex S3; COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 homolog; COP9 signalosome complex subunit 3; COP9 signalosome subunit 3; COP9 subunit 3; COPS 3; cops3; CSN 3; CSN3; CSN3_HUMAN; JAB 1 containing signalosome subunit 3; JAB1 containing signalosome subunit 3; JAB1-containing signalosome subunit 3; SGN 3; SGN3; Signalosome subunit 3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-423
  • 氨基酸序列
    ASALEQFVN SVRQLSAQGQ MTQLCELINK SGELLAKNLS HLDTVLGALD VQEHSLGVLA VLFVKFSMPS VPDFETLFSQ VQLFISTCNG EHIRYATDTF AGLCHQLTNA LVERKQPLRG IGILKQAIDK MQMNTNQLTS IHADLCQLCL LAKCFKPALP YLDVDMMDIC KENGAYDAKH FLCYYYYGGM IYTGLKNFER ALYFYEQAIT TPAMAVSHIM LESYKKYILV SLILLGKVQQ LPKYTSQIVG RFIKPLSNAY HELAQVYSTN NPSELRNLVN KHSETFTRDN NMGLVKQCLS SLYKKNIQRL TKTFLTLSLQ DMASRVQLSG PQEAEKYVLH MIEDGEIFAS INQKDGMVSF HDNPEKYNNP AMLHNIDQEM LKCIELDERL KAMDQEITVN PQFVQKSMGS QEDDSGNKPS SYS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • 基因功能參考文獻:
    1. Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation. PMID: 28891468
    2. this study demonstrates Csn3 as an oncogene that regulates the tumorigenesis process in hepatocellular carcinoma (HCC) cells. PMID: 22237956
    3. of the COPS3 gene might have important roles in metastasis of osteosarcoma cells. PMID: 21436869
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    CSN3 family
  • 組織特異性:
    Widely expressed. Expressed at high level in heart and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 2239

    OMIM: 604665

    KEGG: hsa:8533

    STRING: 9606.ENSP00000268717

    UniGene: Hs.6076



主站蜘蛛池模板: 狠人干练合综合网| 亚洲蜜桃精久久久久久久久久久久| 欧美午夜成人片在线观看| 午夜不卡av免费| 免费国产黄网站在线观看动图| 2019最新久久久视频精品| 无码午夜福利视频1000集| 欧美精品亚洲精品日韩专区一乛方| 日韩成人无码影院| 国产成人无码区免费内射一片色欲| 99re6热精品视频在线观看| 性中国妓女毛茸茸视频| 亚洲精品无码鲁网中文电影| 色婷婷亚洲一区二区三区| 亚洲啪啪综合av一区| 无码国产精品一区二区免费vr| 精品国产乱码久久久久久乱码| 亚洲精品乱码久久久久蜜桃| 成人网站在线进入爽爽爽| 在线观看的网站| 国产免费又色又爽又黄软件| 又色又爽又黄的视频国内 | 全部孕妇毛片| 综合无码精品人妻一区二区三区| 精品动漫一区二区无遮挡| 欧洲吸奶大片在线看| 性欧美疯狂xxxxbbbb| 国产超碰人人模人人爽人人喊 | 精品久久综合1区2区3区激情 | 成熟了的熟妇毛茸茸| 人妻精品制服丝袜久久久| 99久在线国内在线播放免费观看| 国产亚洲精品美女久久久| 国产精品无码人妻一区二区在线| 久久先锋男人av资源网站| 中文日产乱幕九区无线码| 欧美3p两根一起进高清视频| 欧美 日韩 人妻 高清 中文| 四虎影视88aa久久人妻| 日本一区不卡高清更新二区| 亚洲精品日本久久一区二区三区|