在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human C-type lectin domain family 5 member A (CLEC5A), partial

Recombinant Human C-type lectin domain family 5 member A (CLEC5A), partial

  • 中文名稱：
    Recombinant Human C-type lectin domain family 5 member A(CLEC5A),partial
  • 貨號：
    CSB-YP873686HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 5 member A(CLEC5A),partial
  • 貨號：
    CSB-EP873686HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 5 member A(CLEC5A),partial
  • 貨號：
    CSB-EP873686HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 5 member A(CLEC5A),partial
  • 貨號：
    CSB-BP873686HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human C-type lectin domain family 5 member A(CLEC5A),partial
  • 貨號：
    CSB-MP873686HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CLEC5A
  • Uniprot No.：
  • 別名：
    C type lectin domain family 5 member A; C-type lectin domain family 5 member A; C-type lectin superfamily member 5; CLC5A_HUMAN; CLEC5 A; CLEC5A; CLECSF 5; CLECSF5; MDL 1; MDL-1; MDL1; Myeloid DAP12 associating lectin; Myeloid DAP12-associating lectin 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

相關產品

靶點詳情

  • 功能：
    Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.; (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • 基因功能參考文獻：
    1. MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. PMID: 29126450
    2. this study shows association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity PMID: 28764923
    3. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis PMID: 27033255
    4. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
    5. The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. PMID: 27795434
    6. Concordant overexpression of MDL-1 and DAP12 were correlated with increased production of proinflammatory cytokines in rheumatoid arthritis patients. PMID: 24465901
    7. Blockade of CLEC5A inhibits NLRP3 inflammasome activation and pyrotopsis in dengue-virus-infected inflammatory macrophages. Thus, DV can activate NLRP3 inflammasome via CLEC5A. PMID: 23152543
    8. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and Kawasaki disease patients. PMID: 22536019
    9. CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. PMID: 21566123
    10. CLEC5A expression in monocyte/macrophage and granulocytes is regulated by PU.1. PMID: 21094529
    11. The crystal volume per unit weight (VM) was calculated to be 2.34 A3 Da-1, with nine molecules per asymmetric unit and a solvent content of 47.38%. CLEC5A plays an important role in the pathophysiology of dengue-virus-induced disease. PMID: 20057064
    12. blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with Dengue virus (either alone or complexed with an enhancing antibody) PMID: 18496526

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated
  • 數據庫鏈接：

    HGNC: 2054

    OMIM: 604987

    KEGG: hsa:23601

    STRING: 9606.ENSP00000449999

    UniGene: Hs.446235



主站蜘蛛池模板： 久久综合伊人中文字幕| 国产美女a做受大片观看| 美女扒开腿让男人桶爽揉| 熟妇高潮一区二区三区| 久人人爽人人爽人人片av| 国产熟妇高潮呻吟喷水| 人妻丰满熟妇a无码区| 中文字幕日韩人妻无码| 久久久www成人免费无遮挡大片| 国产成人av综合久久| 久久男人av资源网站| 国产杨幂av在线播放| 欧美老妇大p毛茸茸| 亚洲337少妇裸体艺术| 伊人色综合网久久天天| 中文字幕乱偷无码av先锋| 欧美一区内射最近更新| 波多野结衣爽到高潮大喷| 一本大道大臿蕉视频无码| 免费人成自慰网站| 国产精品无码专区在线观看| 国产成人亚洲综合图区| 国产精品无码一区二区在线观一| 中国美女毛茸茸撒尿| 免费人妻精品一区二区三区 | 丰满多毛的大隂户视频| 色欲av巨乳无码一区二区| 欧美亚洲另类自拍丝袜| 青青草大香焦在线综合视频| 99热久久这里只有精品| 亚洲欧美日韩视频高清专区 | 一本一道久久a久久精品综合| 手机看片福利一区二区三区| 日日橹狠狠爱欧美视频| 欧美3p两根一起进高清视频| 18禁男女爽爽爽午夜网站免费| 国产免费一卡二卡三卡四卡| 色综合无码av网站| 在线a亚洲视频播放在线观看| 日韩 欧美 国产 一区三| 尹人香蕉99久久综合网站|