在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLEC5A Antibody

  • 中文名稱:
    CLEC5A兔多克隆抗體
  • 貨號:
    CSB-PA163406
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA163406(CLEC5A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA163406(CLEC5A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CLEC5A
  • 別名:
    C type lectin domain family 5 member A antibody; C-type lectin domain family 5 member A antibody; C-type lectin superfamily member 5 antibody; CLC5A_HUMAN antibody; CLEC5 A antibody; CLEC5A antibody; CLECSF 5 antibody; CLECSF5 antibody; MDL 1 antibody; MDL-1 antibody; MDL1 antibody; Myeloid DAP12 associating lectin antibody; Myeloid DAP12-associating lectin 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human CLEC5A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.; (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP. This interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
  • 基因功能參考文獻:
    1. MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival. PMID: 29126450
    2. this study shows association of rs1285933 single nucleotide polymorphism in CLEC5A gene with dengue severity PMID: 28764923
    3. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis PMID: 27033255
    4. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
    5. The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals. PMID: 27795434
    6. Concordant overexpression of MDL-1 and DAP12 were correlated with increased production of proinflammatory cytokines in rheumatoid arthritis patients. PMID: 24465901
    7. Blockade of CLEC5A inhibits NLRP3 inflammasome activation and pyrotopsis in dengue-virus-infected inflammatory macrophages. Thus, DV can activate NLRP3 inflammasome via CLEC5A. PMID: 23152543
    8. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and Kawasaki disease patients. PMID: 22536019
    9. CLEC5A is homodimeric at the cell surface and binds to dengue virus serotypes 1-4. PMID: 21566123
    10. CLEC5A expression in monocyte/macrophage and granulocytes is regulated by PU.1. PMID: 21094529
    11. The crystal volume per unit weight (VM) was calculated to be 2.34 A3 Da-1, with nine molecules per asymmetric unit and a solvent content of 47.38%. CLEC5A plays an important role in the pathophysiology of dengue-virus-induced disease. PMID: 20057064
    12. blockade of CLEC5A-mediated signalling attenuates the production of proinflammatory cytokines by macrophages infected with Dengue virus (either alone or complexed with an enhancing antibody) PMID: 18496526

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Highly expressed in bone marrow with lower levels in synovium, lung and bronchus. Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated
  • 數據庫鏈接:

    HGNC: 2054

    OMIM: 604987

    KEGG: hsa:23601

    STRING: 9606.ENSP00000449999

    UniGene: Hs.446235



主站蜘蛛池模板: 色噜噜狠狼综合在线| 性生交大片免费看| 国产精品国色综合久久| 国产精品亚洲五月天高清| 女乱高潮久久久久久爽爽| 无码专区手机在线播放| 国产又粗又猛又爽又黄的视频在线观看动漫| 少妇人妻邻居| 亚洲成h人av无码动漫无遮挡| 免费观看国产小粉嫩喷水| 果冻传媒亚洲区二期| 女人高潮内射99精品| 极品嫩模高潮叫床| 国产丰满麻豆vⅰde0sex| 色偷偷一区二区无码视频| 国产精品特级毛片一区二区三区| 中文无码精品a∨在线观看不卡| 午夜性色吃奶添下面69影院 | 成年午夜性影院免费观看| 色欲人妻aaaaaa无码| 伊人久久大香线蕉av五月天| 国产一精品一av一免费| 欧美老熟妇喷水| 免费看撕开奶罩揉吮奶头视频 | 久久精品久久电影免费理论片| 中文字日产乱码免费1~3软件| 东京热人妻丝袜av无码| 亚洲中文字幕无码爆乳av| 国产亚洲日韩在线三区| 蜜臀av色欲a片无码一区| 欧美熟妇性xxx交潮喷| 中文在线√天堂| 人妻熟女av一区二区三区| 亚洲精品图片区小说区| 又粗又硬又大又爽免费视频播放| 免费人成在线观看网站品善网| 18禁美女黄网站色大片在线| 天堂中文а√在线官网| 国产精品久久久久久妇女| 日韩av爽爽爽久久久久久| 国产欧美日韩中文久久|