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  4. Recombinant Human Bromodomain and WD repeat-containing protein 3 (BRWD3), partial

Recombinant Human Bromodomain and WD repeat-containing protein 3 (BRWD3), partial

  • 中文名稱：
    Recombinant Human Bromodomain and WD repeat-containing protein 3(BRWD3) ,partial
  • 貨號：
    CSB-YP744191HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain and WD repeat-containing protein 3(BRWD3) ,partial
  • 貨號：
    CSB-EP744191HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain and WD repeat-containing protein 3(BRWD3) ,partial
  • 貨號：
    CSB-EP744191HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain and WD repeat-containing protein 3(BRWD3) ,partial
  • 貨號：
    CSB-BP744191HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Bromodomain and WD repeat-containing protein 3(BRWD3) ,partial
  • 貨號：
    CSB-MP744191HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BRWD3
  • Uniprot No.：
  • 別名：
    BRWD3Bromodomain and WD repeat-containing protein 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能參考文獻：
    1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
    2. A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly. PMID: 24462886
    3. potential serological biomarker of breast cancer PMID: 22024541
    4. Includes the identification of truncating mutations in this gene that segregated with mental retardation in the families tested. PMID: 19377476
    5. BRWD3 is therefore a new gene implicated in the etiology of XLMR associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. PMID: 17668385

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  • 相關疾病：
    Mental retardation, X-linked 93 (MRX93)
  • 組織特異性：
    Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.
  • 數據庫鏈接：

    HGNC: 17342

    OMIM: 300553

    KEGG: hsa:254065

    STRING: 9606.ENSP00000362372

    UniGene: Hs.147027



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