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  4. BRWD3 Antibody

BRWD3 Antibody

  • 中文名稱：
    BRWD3兔多克隆抗體
  • 貨號：
    CSB-PA008526
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    BRWD3
  • 別名：
    BRWD3Bromodomain and WD repeat-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human BRWD3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能參考文獻：
    1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
    2. A nonsense mutation in BRWD3 in a family with X-linked intellectual disability associated with macrocephaly. PMID: 24462886
    3. potential serological biomarker of breast cancer PMID: 22024541
    4. Includes the identification of truncating mutations in this gene that segregated with mental retardation in the families tested. PMID: 19377476
    5. BRWD3 is therefore a new gene implicated in the etiology of XLMR associated with macrocephaly and may cause disease by altering intracellular signaling pathways affecting cellular proliferation. PMID: 17668385

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  • 相關疾病：
    Mental retardation, X-linked 93 (MRX93)
  • 組織特異性：
    Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.
  • 數據庫鏈接：

    HGNC: 17342

    OMIM: 300553

    KEGG: hsa:254065

    STRING: 9606.ENSP00000362372

    UniGene: Hs.147027



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