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  4. Recombinant Human Armadillo repeat-containing protein 5 (ARMC5), partial

Recombinant Human Armadillo repeat-containing protein 5 (ARMC5), partial

  • 中文名稱：
    Recombinant Human Armadillo repeat-containing protein 5(ARMC5) ,partial
  • 貨號：
    CSB-YP839299HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Armadillo repeat-containing protein 5(ARMC5) ,partial
  • 貨號：
    CSB-EP839299HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Armadillo repeat-containing protein 5(ARMC5) ,partial
  • 貨號：
    CSB-EP839299HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Armadillo repeat-containing protein 5(ARMC5) ,partial
  • 貨號：
    CSB-BP839299HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Armadillo repeat-containing protein 5(ARMC5) ,partial
  • 貨號：
    CSB-MP839299HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARMC5
  • Uniprot No.：
  • 別名：
    Armadillo repeat containing 5; Armadillo repeat-containing protein 5; Armc5; ARMC5_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production.
  • 基因功能參考文獻：
    1. The ARMC5 germline alterations c.1214delG (p.(Gly405Alafs*56)), c.318delG (p.(Ser107Argfs*30)), c.2564delT (p.(Val855Glyfs*62)), c.622_623insC (p.(Gln208Profs*15)) and c.523delG (p.(Ala175Profs*7)) were identified in 5 out of the 23 (21.7%) sporadic primary bilateral macronodular adrenal hyperplasia patients. PMID: 29370219
    2. ARMC5 mutations are not present in a fairly large series of Caucasian patients with primary aldosteronism associated with bilateral adrenal disease. PMID: 26446392
    3. ARMC5 expression pattern in human tissues is reported. PMID: 27568465
    4. ARMC5 mutations are frequent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia and seem to be associated with a particular pattern of the adrenal masses. PMID: 27094308
    5. This is the first report demonstrating germline deletion of ARMC5 in familial primary macronodular adrenal hyperplasia. PMID: 26214113
    6. study describes members of a French-Canadian bilateral macronodular adrenal hyperplasia kindred with beta-adrenergic and V1-vasopressin regulation of cortisol including 7 with subclinical and 2 with clinical Cushing syndrome; a heterozygous germline ARMC5 mutation was identified in the index case that segregates with the disease PMID: 26604299
    7. Germline ARMC5 variants may be associated with primary aldosteronism. PMID: 25822102
    8. ARMC5 germline mutations are common in primary macronodular adrenal hyperplasia(PBMAH).ARMC5 genotyping may help to identify clinical forms of PBMAH better and may also allow earlier diagnosis of this disease. PMID: 25853793
    9. Our studies have detected ARMC5 mutations in 4 of 5 bilateral macronodular adrenal hyperplasia families tested. PMID: 24905064
    10. Inherited autosomal dominant mutations in the ARMC5 gene are a frequent cause of primary macronodular adrenal hyperplasia. Biallelic inactivation of ARMC5 is consistent with its role as a potential tumor suppressor gene. PMID: 24708098
    11. ARMC5 mutations are implicated in clinically severe Cushing's syndrome associated with Macronodular adrenal hyperplasia. PMID: 24601692
    12. Some cases of corticotropin-independent macronodular adrenal hyperplasia appear to be genetic, most often with inactivating mutations of ARMC5. PMID: 24283224

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  • 相關疾病：
    ACTH-independent macronodular adrenal hyperplasia 2 (AIMAH2)
  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：

    HGNC: 25781

    OMIM: 615549

    KEGG: hsa:79798

    STRING: 9606.ENSP00000268314

    UniGene: Hs.732945



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