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  4. Recombinant Human Angiomotin-like protein 1 (AMOTL1), partial

Recombinant Human Angiomotin-like protein 1 (AMOTL1), partial

  • 中文名稱：
    Recombinant Human Angiomotin-like protein 1(AMOTL1) ,partial
  • 貨號：
    CSB-YP812894HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Angiomotin-like protein 1(AMOTL1) ,partial
  • 貨號：
    CSB-EP812894HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Angiomotin-like protein 1(AMOTL1) ,partial
  • 貨號：
    CSB-EP812894HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Angiomotin-like protein 1(AMOTL1) ,partial
  • 貨號：
    CSB-BP812894HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Angiomotin-like protein 1(AMOTL1) ,partial
  • 貨號：
    CSB-MP812894HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AMOTL1
  • Uniprot No.：
  • 別名：
    2310010G08Rik; 2310067L22Rik; 4932416D09Rik; AMOL1_HUMAN; Amotl1; Angiomotin-like protein 1; FLJ00155; JEAP; Junction enriched and associated protein; mFLJ00155
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
  • 基因功能參考文獻：
    1. AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. PMID: 26806348
    2. phosphorylation-deficient S793Ala mutant of AMOTL1 showed a shorter half-life and conferred resistance to energy-stress-induced YAP inhibition. PMID: 25373897
    3. miR-124 binds AmotL1 3'UTR and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells. PMID: 25218344
    4. These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs. PMID: 23793505
    5. AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. PMID: 21685940
    6. By yeast two-hybrid screening, angiomotin-like 1 (AmotL1) was identified as a host factor that interacts with the M protein of parainfluenza virus 5 (PIV5). PMID: 19932912

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  • 亞細胞定位：
    Cell junction, tight junction.
  • 蛋白家族：
    Angiomotin family
  • 數據庫鏈接：

    HGNC: 17811

    OMIM: 614657

    KEGG: hsa:154810

    STRING: 9606.ENSP00000387739

    UniGene: Hs.503594



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