在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Amyloid beta precursor like protein 2 (APLP2 APPL2)

Recombinant Human Amyloid beta precursor like protein 2 (APLP2 APPL2)

  • 中文名稱：
  • 貨號：
    CSB-YP001912HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP001912HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP001912HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP001912HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP001912HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Amyloid beta precursor like protein 2; APPH; Amyloid beta; A4; precursor-like protein 2; Amyloid protein homolog; Amyloid-like protein 2; APLP-2; CDEI box-binding protein; CDEBP; Sperm membrane protein YWK-II; APLP2 APPL2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
  • 基因功能參考文獻：
    1. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma PMID: 29663738
    2. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. PMID: 27796194
    3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
    4. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases. PMID: 25576918
    5. We conclude that PCSK9 enhances the degradation of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice. PMID: 26085104
    6. our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells. PMID: 22797723
    7. amyloid precursor protein-like protein-2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function PMID: 23430252
    8. Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. PMID: 22641691
    9. APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. PMID: 21952790
    10. APLP-2 (and APLP1) are capable of activating gene transcription via binding to Mint3. PMID: 21178287
    11. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. PMID: 21826533
    12. The interaction between APLP2 and ataxin-7 and proteolytic processing of APLP2 may contribute to the pathogenesis of spinocerebellar ataxia type 7. PMID: 20732423
    13. APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain are able to enhance Fe65-dependent gene activation PMID: 12228233
    14. crystals of extracellular fragment X3 of a human sperm membrane protein YWK-II/APPH have been grow by the vapour-diffusion method [YWK-II PROTEIN] PMID: 12595709
    15. Sustained levels of APP and the elevated levels of APLP2, in spite of the reduced mRNA expression, are due to altered proteolytic processing of these proteins. PMID: 14597230
    16. The APLP2 gene has no CAGA box, but it does have a GAGA sequence in a location similar to that of the CAGA box in the APP gene. PMID: 15208260
    17. Interaction of human and murine Abeta peptides, Abeta40 and Abeta42. Interspecies Abeta aggregates and fibres are readily formed and are more stable than homogenous human fibres. (Amyloid beta 40 and 42) PMID: 15584916
    18. APLP2 is shed by disintegrins and metalloproteinases. Overexpression of secretase or TACE in HEK293 cells increases the release of neurotrophic soluble APLP2 severalfold. PMID: 16279945
    19. findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients PMID: 16645641
    20. APLP2 and APP have roles in sperm function PMID: 17405931
    21. YWK-II (APLP2 protein) is a G(o)-coupled receptor for Mullerian inhibiting substance in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival. PMID: 17452623
    22. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
    23. APLP2 modulates the stability and endocytosis of K(d) molecules PMID: 18641335
    24. APLP2 has a multistep trafficking function that influences the expression of major histocompatibility complex class I molecules at the plasma membrane PMID: 19808674

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    APP family
  • 組織特異性：
    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
  • 數據庫鏈接：

    HGNC: 598

    OMIM: 104776

    KEGG: hsa:334

    STRING: 9606.ENSP00000263574

    UniGene: Hs.370247



主站蜘蛛池模板： 中文www新版资源在线| 亚洲精品国产美女久久久99| 国产中的精品av一区二区| 国产高清在线精品一区二区三区 | 亚洲偷自拍国综合| 久久婷婷五月综合97色直播| 日韩精品一区国产偷窥在线| 日韩人妻无码精品系列| 国内精品久久久久久久电影视| 精品久久久久久中文字幕大豆网| 一本色道久久综合无码人妻| 久久人人爽人人爽人人av东京热 | 成人一区二区免费视频| 国产成人三级一区二区在线观看一| 特黄 做受又硬又粗又大视频| 大屁股国产白浆一二区| 日韩不卡1卡2卡三卡2021精品推荐 | 日韩精品久久久免费观看| 77777_亚洲午夜久久多人| 高h纯肉无码视频在线观看| 看黄a大片爽爽影院免费无码| 艳妇乳肉豪妇荡乳在线观看| 夜夜高潮天天爽欧美| 少妇无码吹潮| 日本成本人片视频免费 | 国产肉丝袜视频在线观看| 小罗莉极品一线天在线| 人妻夜夜爽天天爽三区丁香花| 欧美黑人与白人精品a片| 亚洲精品成人av观看| 中文字幕一精品亚洲无线一区| 亚洲精品～无码抽插| 日本亚洲欧美在线视观看| 国产免费踩踏调教视频| 久久这里只精品国产免费10 | 亚瑟av亚洲精品一区二区| av在线播放日韩亚洲欧| 成人看的污污超级黄网站免费| 人人妻人人澡人人爽偷拍台湾| 国产av人人夜夜澡人人爽麻豆 | 亚洲第一区无码专区|