在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. APLP2 Antibody

APLP2 Antibody

  • 中文名稱：
    APLP2兔多克隆抗體
  • 貨號：
    CSB-PA000903
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 3T3 cells using APLP-2 Polyclonal Antibody
    • Western Blot analysis of 293 NIH-3T3 cells using APLP-2 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    amyloid beta (A4) precursor like protein 2 antibody; Amyloid like protein 2 antibody; Amyloid precursor protein homolog HSD 2 antibody; amyloid precursor protein homolog HSD2 antibody; Amyloid protein homolog antibody; Amyloid-like protein 2 antibody; APLP-2 antibody; Aplp2 antibody; APLP2_HUMAN antibody; APPH antibody; APPL2 antibody; CDEBP antibody; CDEI box binding protein antibody; CDEI box-binding protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human APLP-2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
  • 基因功能參考文獻(xiàn)：
    1. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma PMID: 29663738
    2. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. PMID: 27796194
    3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
    4. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases. PMID: 25576918
    5. We conclude that PCSK9 enhances the degradation of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice. PMID: 26085104
    6. our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells. PMID: 22797723
    7. amyloid precursor protein-like protein-2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function PMID: 23430252
    8. Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. PMID: 22641691
    9. APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. PMID: 21952790
    10. APLP-2 (and APLP1) are capable of activating gene transcription via binding to Mint3. PMID: 21178287
    11. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. PMID: 21826533
    12. The interaction between APLP2 and ataxin-7 and proteolytic processing of APLP2 may contribute to the pathogenesis of spinocerebellar ataxia type 7. PMID: 20732423
    13. APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain are able to enhance Fe65-dependent gene activation PMID: 12228233
    14. crystals of extracellular fragment X3 of a human sperm membrane protein YWK-II/APPH have been grow by the vapour-diffusion method [YWK-II PROTEIN] PMID: 12595709
    15. Sustained levels of APP and the elevated levels of APLP2, in spite of the reduced mRNA expression, are due to altered proteolytic processing of these proteins. PMID: 14597230
    16. The APLP2 gene has no CAGA box, but it does have a GAGA sequence in a location similar to that of the CAGA box in the APP gene. PMID: 15208260
    17. Interaction of human and murine Abeta peptides, Abeta40 and Abeta42. Interspecies Abeta aggregates and fibres are readily formed and are more stable than homogenous human fibres. (Amyloid beta 40 and 42) PMID: 15584916
    18. APLP2 is shed by disintegrins and metalloproteinases. Overexpression of secretase or TACE in HEK293 cells increases the release of neurotrophic soluble APLP2 severalfold. PMID: 16279945
    19. findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients PMID: 16645641
    20. APLP2 and APP have roles in sperm function PMID: 17405931
    21. YWK-II (APLP2 protein) is a G(o)-coupled receptor for Mullerian inhibiting substance in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival. PMID: 17452623
    22. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
    23. APLP2 modulates the stability and endocytosis of K(d) molecules PMID: 18641335
    24. APLP2 has a multistep trafficking function that influences the expression of major histocompatibility complex class I molecules at the plasma membrane PMID: 19808674

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族：
    APP family
  • 組織特異性：
    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 598

    OMIM: 104776

    KEGG: hsa:334

    STRING: 9606.ENSP00000263574

    UniGene: Hs.370247



主站蜘蛛池模板： 久人人爽人人爽人人片av| 亚洲性无码av中文字幕| 欧美一性一乱一交一视频| 国产97公开成人免费视频在线观看| 性荡视频播放在线视频| 午夜亚洲乱码伦小说区69堂| 中字幕视频在线永久在线| 精品伊人久久久大香线蕉下载| 日韩人妻中文无码一区二区三区 | 天天躁日日躁狠狠躁性色avq| 国内最真实的xxxx人伦| 毛片24种姿势无遮无拦| 性欧美疯狂xxxxbbbb| 国产熟妇另类久久久久久| 亚洲国产天堂久久综合网| 极品少妇被猛的白浆直喷白浆| 国产丶欧美丶日本不卡视频| 男女吃奶做爰猛烈紧视频| 人人妻人人爽人人澡欧美一区 | 小鲜肉洗澡时自慰网站xnxx| 国产偷国产偷亚州清高app | 亚洲精品一品区二品区三区| 国产av福利久久| 亚洲人成人影院在线观看| 国产午夜亚洲精品午夜鲁丝片| 欧美一区二区三区久久综合| 成在人线av无码免费高潮水老板 | 吸咬奶头狂揉60分钟视频| 丰满饥渴老女人hd| 玩弄少妇的肉体k8经典| 天堂网在线www资源| 国产又粗又猛又爽又黄| 国自产拍偷拍精品啪啪一区二区| 亚洲妇女水蜜桃av网网站| 亚洲男人综合久久综合天堂| 嫩草研究院久久久精品| 国产人与禽zoz0性伦多活几年| 99国产精品白浆在线观看免费| 国产精品毛片完整版视频| 国精产品48x国精产品| 久久精品国产丝袜人妻|