在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APLP2 Antibody

  • 中文名稱:
    APLP2兔多克隆抗體
  • 貨號:
    CSB-PA001912DSR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001912DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA001912DSR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) APLP2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    amyloid beta (A4) precursor like protein 2 antibody; Amyloid like protein 2 antibody; Amyloid precursor protein homolog HSD 2 antibody; amyloid precursor protein homolog HSD2 antibody; Amyloid protein homolog antibody; Amyloid-like protein 2 antibody; APLP-2 antibody; Aplp2 antibody; APLP2_HUMAN antibody; APPH antibody; APPL2 antibody; CDEBP antibody; CDEI box binding protein antibody; CDEI box-binding protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Amyloid-like protein 2 protein (340-450AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
  • 基因功能參考文獻:
    1. the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma PMID: 29663738
    2. These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. PMID: 27796194
    3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
    4. Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases. PMID: 25576918
    5. We conclude that PCSK9 enhances the degradation of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice. PMID: 26085104
    6. our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells. PMID: 22797723
    7. amyloid precursor protein-like protein-2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function PMID: 23430252
    8. Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. PMID: 22641691
    9. APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. PMID: 21952790
    10. APLP-2 (and APLP1) are capable of activating gene transcription via binding to Mint3. PMID: 21178287
    11. Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. PMID: 21826533
    12. The interaction between APLP2 and ataxin-7 and proteolytic processing of APLP2 may contribute to the pathogenesis of spinocerebellar ataxia type 7. PMID: 20732423
    13. APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain are able to enhance Fe65-dependent gene activation PMID: 12228233
    14. crystals of extracellular fragment X3 of a human sperm membrane protein YWK-II/APPH have been grow by the vapour-diffusion method [YWK-II PROTEIN] PMID: 12595709
    15. Sustained levels of APP and the elevated levels of APLP2, in spite of the reduced mRNA expression, are due to altered proteolytic processing of these proteins. PMID: 14597230
    16. The APLP2 gene has no CAGA box, but it does have a GAGA sequence in a location similar to that of the CAGA box in the APP gene. PMID: 15208260
    17. Interaction of human and murine Abeta peptides, Abeta40 and Abeta42. Interspecies Abeta aggregates and fibres are readily formed and are more stable than homogenous human fibres. (Amyloid beta 40 and 42) PMID: 15584916
    18. APLP2 is shed by disintegrins and metalloproteinases. Overexpression of secretase or TACE in HEK293 cells increases the release of neurotrophic soluble APLP2 severalfold. PMID: 16279945
    19. findings show an increase in the immunoreactivities for the nuclear C-terminal fragments of APLP2 and for GSK-3beta in the brains of Alzheimer disease patients PMID: 16645641
    20. APLP2 and APP have roles in sperm function PMID: 17405931
    21. YWK-II (APLP2 protein) is a G(o)-coupled receptor for Mullerian inhibiting substance in mediating ERK1/2 activation leading to anti-apoptotic activity or cell survival. PMID: 17452623
    22. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
    23. APLP2 modulates the stability and endocytosis of K(d) molecules PMID: 18641335
    24. APLP2 has a multistep trafficking function that influences the expression of major histocompatibility complex class I molecules at the plasma membrane PMID: 19808674

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Nucleus.
  • 蛋白家族:
    APP family
  • 組織特異性:
    Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues.
  • 數據庫鏈接:

    HGNC: 598

    OMIM: 104776

    KEGG: hsa:334

    STRING: 9606.ENSP00000263574

    UniGene: Hs.370247



主站蜘蛛池模板: 无限看片在线版免费视频大全| 成人免费毛片内射美女app| 成人免费无码视频在线网站| 国产乱妇无码大片在线观看| 国产精品爽爽va吃奶在线观看| 人妻互换一二三区激情视频| 国产97色在线 | 免| 午夜视频无码国产在线观看| 亚洲大色堂人在线无码| 欧美精品v欧洲精品| 国产后入又长又硬| 无码人妻一区二区三区在线视频 | 日本添下边视频全过程 | 女人裸露免费视频无遮挡网站| 亚洲小说春色综合另类| 老鲁夜夜老鲁| 高潮喷水无码av亚洲| 精品婷婷色一区二区三区| 男女一边摸一边做爽爽的免费阅读| 夜先锋av资源网站| 免费观看又色又爽又黄的崩锅| 蜜臀久久99精品久久久久久做爰 | 久久国产精品久久久久久| 精品福利视频一区二区三区| 亚洲va久久久噜噜噜久久天堂| 免费国产成人午夜福利电影| 丰满少妇人妻无码| 国产亚洲一区二区在线观看| 中文字幕久久久久人妻中出| 中文字幕久久久久人妻| 欧美伊人久久大香线蕉综合| 国产精品制服| 未满十八18禁止午夜免费网站| 群交射精白浆视频| 国产精品亚洲专区无码web| 国产精品69人妻无码久久| 在线亚洲97se亚洲综合在线| 可以直接免费观看的av网站| 麻豆国产精品va在线观看| 激情无码人妻又粗又大中国人| 亚洲精品欧美二区三区中文字幕|