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Recombinant Human Aminomethyltransferase, mitochondrial (AMT)

  • 中文名稱:
    Recombinant Human Aminomethyltransferase, mitochondrial(AMT)
  • 貨號:
    CSB-YP001684HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Aminomethyltransferase, mitochondrial(AMT)
  • 貨號:
    CSB-EP001684HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Aminomethyltransferase, mitochondrial(AMT)
  • 貨號:
    CSB-EP001684HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Aminomethyltransferase, mitochondrial(AMT)
  • 貨號:
    CSB-BP001684HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Aminomethyltransferase, mitochondrial(AMT)
  • 貨號:
    CSB-MP001684HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AMT
  • Uniprot No.:
  • 別名:
    Aminomethyltransferase (glycine cleavage system protein T) ; Aminomethyltransferase; AMT; GCE ; GCST ; GCST_HUMAN; GCVT; Glycine cleavage system T protein; mitochondrial; NKH
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區(qū)域:
    29-403
  • 氨基酸序列
    AQ EVLRRTPLYD FHLAHGGKMV AFAGWSLPVQ YRDSHTDSHL HTRQHCSLFD VSHMLQTKIL GSDRVKLMES LVVGDIAELR PNQGTLSLFT NEAGGILDDL IVTNTSEGHL YVVSNAGCWE KDLALMQDKV RELQNQGRDV GLEVLDNALL ALQGPTAAQV LQAGVADDLR KLPFMTSAVM EVFGVSGCRV TRCGYTGEDG VEISVPVAGA VHLATAILKN PEVKLAGLAA RDSLRLEAGL CLYGNDIDEH TTPVEGSLSW TLGKRRRAAM DFPGAKVIVP QLKGRVQRRR VGLMCEGAPM RAHSPILNME GTKIGTVTSG CPSPSLKKNV AMGYVPCEYS RPGTMLLVEV RRKQQMAVVS KMPFVPTNYY TLK
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The glycine cleavage system catalyzes the degradation of glycine.
  • 基因功能參考文獻:
    1. The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT PMID: 27362913
    2. Data indicate no mutation was found in glycine cleavage system protein-H (GCSH) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT) are the main cause of glycine encephalopathy in Malaysian population. PMID: 25231368
    3. Two unique non-synonymous changes were identified in the AMT gene in patients with neural tube defects. PMID: 22171071
    4. x-ray crystallographic structure of human T-protein of glycine cleavage system PMID: 16051266
  • 相關疾病:
    Non-ketotic hyperglycinemia (NKH)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    GcvT family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 473

    OMIM: 238310

    KEGG: hsa:275

    STRING: 9606.ENSP00000273588

    UniGene: Hs.102



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