在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Alpha-endosulfine (ENSA)

  • 中文名稱:
    人ENSA重組蛋白
  • 貨號:
    CSB-RP017044h
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ENSA
  • Uniprot No.:
  • 別名:
    ENSAAlpha-endosulfine; ARPP-19e
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    40.4kDa
  • 表達區域:
    1-121aa
  • 氨基酸序列
    MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
  • 基因功能參考文獻:
    1. The extended S phase in Ensa-depleted cells is completely rescued by the overexpression of Treslin. PMID: 28785014
    2. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa/ARPP19 and Cdk substrate dephosphorylation during mitotic exit. PMID: 24391510
    3. Overexpressed ENSA suppresses tumor growth in an established hepatic cell line whereas hypermethylated ENSA might help maintain liver cancer initiating cells. PMID: 24211627
    4. The considerably decreased alpha-endosulfine could result in the continuous opening of K(ATP) channels and the subsequent decrease of neurotransmitters release associated with cognition in Down Syndrome. PMID: 11771735
    5. We mapped ENSA in silico to chromosome 1q21 near a confirmed type 2 diabetes susceptibility locus, and derived the genomic structure of four exons and three introns. PMID: 14728986
    6. The ENSA gene on 1q21 produces several alternatively spliced transcripts, and is located within a region linked with T2DM in diverse populations including the Pima Indians PMID: 14728987

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Endosulfine family
  • 組織特異性:
    Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas.
  • 數據庫鏈接:

    HGNC: 3360

    OMIM: 603061

    KEGG: hsa:2029

    UniGene: Hs.632456



主站蜘蛛池模板: 日日噜噜夜夜狠狠视频| 久久久久久久性潮| 国产精品丝袜一区二区三区| 久久亚洲精品成人av无码网站| 青青草国产久久精品| 日本成a人片在线播放| 国产成人精品电影在线观看| 久久久国产一区二区三区四区小说| 亚洲国产精品日韩av不卡在线 | 天天综合网亚在线| 亚洲精品亚洲人成在线下载| 国产xxx69麻豆国语对白| 久久精品亚洲一区二区三区浴池| 又大又粗又爽又黄的少妇毛片| 中文无码人妻影音先锋| 亚洲乱码国产一区三区| 久久中文字幕人妻丝袜| 中文字幕乱码一区二区免费| 男女下面一进一出无遮挡| 亚洲精品成人久久久| 国产99视频精品免视看9| 人人爽人人爽人人片a免费| 亚洲 a v无 码免 费 成 人 a v| 久久久久人妻精品一区蜜桃| 国产成人卡2卡3卡4乱码| 亚洲综合久久一本伊一区| 国产精品美女久久久| 国产乱子伦农村叉叉叉| 免费人成激情视频在线观看 | 九九视频在线观看视频6| 成人亚洲欧美久久久久| 国产精品一区二区高清在线| 久久免费的精品国产v∧| 国产成人欧美亚洲日韩电影| 香蕉在线依人视频| 免费看少妇作爱视频| 99国产精品久久久蜜芽| 美女扒开腿让男人桶爽揉| 精品无码人妻一区二区三区| 熟女少妇在线视频播放| 欧美一性一乱一交一免费视频|