在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Alpha-2-macroglobulin-like protein 1 (A2ML1), partial

Recombinant Human Alpha-2-macroglobulin-like protein 1 (A2ML1), partial

  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-YP001005HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-EP001005HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-EP001005HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-BP001005HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-MP001005HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    A2ML1
  • Uniprot No.：
  • 別名：
    A2ML1; CPAMD9Alpha-2-macroglobulin-like protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
  • 基因功能參考文獻(xiàn)：
    1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
    2. The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. PMID: 27484237
    3. A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. PMID: 27799062
    4. Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. PMID: 26121085
    5. our results provide evidence that mutations in A2ML1 are a cause of Noonan-like syndrome, with a variable phenotype ranging from severe to very mild. PMID: 24939586
    6. a new class of target antigens in a paraneoplastic autoimmune multiorgan syndrome PMID: 20805888
    7. alpha2ML1 is the first alpha2macroglobulin family member detected in the epidermis, where it may play an important role during desquamation by inhibiting extracellular proteases. PMID: 16298998
    8. alpha2ML1 binding to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis PMID: 18648652

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性：
    In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23336

    OMIM: 610627

    KEGG: hsa:144568

    STRING: 9606.ENSP00000299698

    UniGene: Hs.620532



主站蜘蛛池模板： 国产成人高清精品亚洲| 日韩一卡二卡三卡四卡免费观在线 | 亚洲成av人片天堂网站| 久久婷婷国产综合精品| 大战熟女丰满人妻av| 末发育女av片一区二区| 久久久久久好爽爽久久| 国产精品妇女一二三区| 欧美牲交a欧美牲交aⅴ图片| 老司机久久一区二区三区| 日韩人妻无码一区二区三区俄罗斯 | 久久精品国产福利一区二区| 国产在线无码视频一区二区三区| 国产日产欧产精品品不卡| 亚洲精品久久久久久久久久吃药| 又黄又爽又高潮免费毛片| 成人免费无码不卡毛片| 欧美性猛交xxxx黑人猛交| 日日澡夜夜澡人人高潮| 好了av在线第四综合网站| 亚洲妇女自偷自偷图片| 搡女人真爽免费视频大全| 婷婷综合久久中文字幕蜜桃三电影| 乱人伦视频中文字幕| 无码中文字幕乱在线观看| ww国产内射精品后入国产| 国产成人午夜福利在线观看视频| 国产亚洲精品久久久999蜜臀| 中文字幕亚洲欧美日韩在线不卡| 久久婷婷五月综合色国产香蕉| 香蕉啪视频在线观看视频久 | 国产精品国产高清国产av| 亚洲国产一区二区波多野结衣| www内射国产在线观看| 国产在线视频www色| 亚洲精品国产品国语在线观看| 日本午夜看x费免| 特黄做受又粗又大又硬老头| 一边添奶一边添p好爽视频| 国产粗话肉麻对白在线播放| 成人无码亚洲精品无码|