在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Alpha-2-macroglobulin-like protein 1 (A2ML1), partial

Recombinant Human Alpha-2-macroglobulin-like protein 1 (A2ML1), partial

  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-YP001005HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-EP001005HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-EP001005HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-BP001005HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Alpha-2-macroglobulin-like protein 1(A2ML1) ,partial
  • 貨號：
    CSB-MP001005HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    A2ML1
  • Uniprot No.：
  • 別名：
    A2ML1; CPAMD9Alpha-2-macroglobulin-like protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
  • 基因功能參考文獻(xiàn)：
    1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
    2. The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. PMID: 27484237
    3. A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. PMID: 27799062
    4. Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. PMID: 26121085
    5. our results provide evidence that mutations in A2ML1 are a cause of Noonan-like syndrome, with a variable phenotype ranging from severe to very mild. PMID: 24939586
    6. a new class of target antigens in a paraneoplastic autoimmune multiorgan syndrome PMID: 20805888
    7. alpha2ML1 is the first alpha2macroglobulin family member detected in the epidermis, where it may play an important role during desquamation by inhibiting extracellular proteases. PMID: 16298998
    8. alpha2ML1 binding to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis PMID: 18648652

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性：
    In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23336

    OMIM: 610627

    KEGG: hsa:144568

    STRING: 9606.ENSP00000299698

    UniGene: Hs.620532



主站蜘蛛池模板： 色偷偷人人澡久久超碰97| 成人麻豆日韩在无码视频| 婷婷丁香五月六月综合激情啪| 成人国产一区二区三区精品不卡 | 欧美xxxxx在线观看| 内射女校花一区二区三区| 国产欧美高清在线观看| 亚洲成色在线综合网站| 久久国产精品国产四虎90后| 正在播放国产乱子伦最新视频| 欧美性白人极品hd| 久久精品国产曰本波多野结衣 | 亚洲精品国产成人精品软件| 精品国产乱码久久久久久口爆| 国产情侣一区二区三区| 一区二区久久久久草草 | 欧美日韩不卡合集视频| 2020无码专区人妻系列日韩| 黑人上司粗大拔不出来电影| 亚洲综合精品香蕉久久网| 国产成人综合在线视频| 免费人成在线观看| 五月花成人网| 久久久久国产精品人妻aⅴ院 | 国产亚洲精品久久久久秋霞不卡 | 少妇饥渴偷公乱av在线观看涩爱 | 漂亮人妻被黑人久久精品| 9l国产精品久久久久尤物| 亚洲国产成人久久综合人 | 国产aⅴ精品一区二区三区久久| 97夜夜澡人人爽人人模人人喊| 风间由美性色一区二区三区| 亚洲国产一区二区波多野结衣| 国产成人精品a∨一区二区| 亚洲人成人网站在线观看| 人妻少妇被粗大爽9797pw| 无线日本视频精品| 国内精品久久人妻互换| 狠狠色综合7777久夜色撩人ⅰ| 一本大道一卡2卡三卡4卡国产| 国产精品亚洲一区二区z|