在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. A2ML1 Antibody, Biotin conjugated

A2ML1 Antibody, Biotin conjugated

  • 中文名稱：
    A2ML1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA001005LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) A2ML1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    A2ML1
  • 別名：
    A2ML1 antibody; CPAMD9Alpha-2-macroglobulin-like protein 1 antibody; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
  • 基因功能參考文獻：
    1. The functional assessment supported the pathogenicity of the RAF1 and RIT1 variants of unknown significance (VUSs), while the significance of two VUSs in A2ML1 remained unclear. PMID: 29402968
    2. The indigenous Filipino population has a ~50% prevalence of otitis media. A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. PMID: 27484237
    3. A2ML1-related otitis media susceptibility may be mediated by changes in the middle ear microbiome. PMID: 27799062
    4. Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. PMID: 26121085
    5. our results provide evidence that mutations in A2ML1 are a cause of Noonan-like syndrome, with a variable phenotype ranging from severe to very mild. PMID: 24939586
    6. a new class of target antigens in a paraneoplastic autoimmune multiorgan syndrome PMID: 20805888
    7. alpha2ML1 is the first alpha2macroglobulin family member detected in the epidermis, where it may play an important role during desquamation by inhibiting extracellular proteases. PMID: 16298998
    8. alpha2ML1 binding to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis PMID: 18648652

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性：
    In the epidermis, expressed predominantly in the granular layer at the apical edge of keratinocytes (at protein level). Also detected in placenta, testis and thymus but not in epithelia of kidney, lung, small intestine or colon.
  • 數據庫鏈接：

    HGNC: 23336

    OMIM: 610627

    KEGG: hsa:144568

    STRING: 9606.ENSP00000299698

    UniGene: Hs.620532



主站蜘蛛池模板： 国产99视频精品免费专区| 亚洲国产精品一区二区美利坚| 久久久久无码国产精品一区| 日韩一本之道一区中文字幕 | 国产精品一区二区久久乐下载| 一本大道无码av天堂| 在线观看成人无码中文av天堂 | 国产午夜精品一区二区三区嫩草| 男女性潮高清免费网站| 无码a∨高潮抽搐流白浆| 亚洲 欧美 综合 另类 中字| 精品久久久久久无码专区不卡| 中文字幕无码日韩欧免费软件| 2021在线不卡国产麻豆| 亚洲国产精品美女久久久久| 成人午夜精品无码区| 亚洲综合日韩久久成人av| 伊人精品成人久久综合97| 国产乱子伦农村xxxx| 大地资源中文第3页| 亚洲一区二区三区成人网站| 97超碰精品成人国产| 人妻出差精油按摩被中出| 亚洲另类激情综合偷自拍图| 青青久在线视频免费观看| 国产做无码视频在线观看浪潮| 亚洲精品无码国产| 亚洲人成色77777在线观看大战p| 欧洲亚洲精品久久久久| 人妻无码中文字幕一区二区三区 | 无限看片在线版免费视频大全| 日本高清www午色夜com| 日韩人妻无码免费视频一二区 | 真人做人试看60分钟免费| 国产高清-国产av| 99久久精品国产波多野结衣| 免费国精产品自偷自偷免费看| 久久久橹橹橹久久久久高清| 久久亚洲国产最新网站之一| 午夜不卡无码中文字幕影院| 激情内射人妻1区2区3区|