在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Alkylated DNA repair protein alkB homolog 8 (ALKBH8)

Recombinant Human Alkylated DNA repair protein alkB homolog 8 (ALKBH8)

  • 中文名稱：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8)
  • 貨號：
    CSB-YP842644HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8)
  • 貨號：
    CSB-EP842644HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8)
  • 貨號：
    CSB-EP842644HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8)
  • 貨號：
    CSB-BP842644HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8)
  • 貨號：
    CSB-MP842644HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ALKBH8
  • Uniprot No.：
  • 別名：
    4930562C03Rik; 8030431D03Rik; 9430088N01Rik; ABH8; alkB alkylation repair homolog 8 (E. coli); alkB alkylation repair homolog 8; AlkB homologue 8; ALKB8_HUMAN; ALKBH8; Alkylated DNA repair protein alkB homolog 8; FLJ38204; MGC10235; OTTHUMP00000211286; OTTHUMP00000211287; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; RGD1304687; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-664
  • 氨基酸序列
    MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE PGQGIPAHID THSAFEDEIV SLSLGSEIVM DFKHPDGIAV PVMLPRRSLL VMTGESRYLW THGITCRKFD TVQASESLKS GIITSDVGDL TLSKRGLRTS FTFRKVRQTP CNCSYPLVCD SQRKETPPSF PESDKEASRL EQEYVHQVYE EIAGHFSSTR HTPWPHIVEF LKALPSGSIV ADIGCGNGKY LGINKELYMI GCDRSQNLVD ICRERQFQAF VCDALAVPVR SGSCDACISI AVIHHFATAE RRVAALQEIV RLLRPGGKAL IYVWAMEQEY NKQKSKYLRG NRNSQGKKEE MNSDTSVQRS LVEQMRDMGS RDSASSVPRI NDSQEGGCNS RQVSNSKLPV HVNRTSFYSQ DVLVPWHLKG NPDKGKPVEP FGPIGSQDPS PVFHRYYHVF REGELEGACR TVSDVRILQS YYDQGNWCVI LQKA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
  • 基因功能參考文獻：
    1. findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer PMID: 27329810
    2. Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. PMID: 21285950
    3. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. PMID: 20123966
    4. Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival. PMID: 20308323
    5. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8. PMID: 19293182

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Widely expressed, with highest expression in spleen, followed by pancreas and lung.
  • 數據庫鏈接：

    HGNC: 25189

    OMIM: 613306

    KEGG: hsa:91801

    STRING: 9606.ENSP00000374219

    UniGene: Hs.503763



主站蜘蛛池模板： 国产精品老熟女露脸视频| 无码毛片内射白浆视频| av老司机亚洲精品天堂| 人妻熟人中文字幕一区二区| av蓝导航精品导航| 999国内精品永久免费观看| 女人高潮抽搐喷液30分钟视频| 国产午夜无码视频在线观看| 正在播放国产真实哭都没用| 欧美伦费免费全部午夜最新| 中文字幕乱码免费| 一本一道波多野结衣av黑人| 香蕉精品亚洲二区在线观看| 久久人妻国产精品31| 免费观看成人毛片a片| 国产情侣真实露脸在线| 久久九九精品国产综合喷水| 免费视频爱爱太爽了| 成人a片产无码免费视频在线观看| 久久综合狠狠综合久久激情| 日韩人妻无码一区二区三区| 在线天堂www在线国语对白| 亚洲成av人无码中文字幕| 五月丁香综合激情六月久久| 国产强被迫伦姧在线观看无码| 国内精品九九久久久精品| 精品国产肉丝袜久久| 国产成人无码av一区二区在线观看| 爱性久久久久久久久| 天天做天天爱天天要天天| 男人女人做爽爽18禁网站| 男男啪啪激烈高潮cc漫画免费 | 欧美综合自拍亚洲综合图片区| 久久国产免费观看精品3| 国产国产精品人在线视| 久久久精品中文字幕麻豆发布| 国内精品久久久久精免费| 最新中文乱码字字幕在线| 51精品国产人成在线观看| 国产精品一区波多野结衣| 国产精品第一区揄拍无码|