在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ALKBH8 Antibody

ALKBH8 Antibody

  • 中文名稱：
    ALKBH8兔多克隆抗體
  • 貨號：
    CSB-PA842644ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA842644ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ALKBH8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ALKBH8
  • 別名：
    4930562C03Rik antibody; 8030431D03Rik antibody; 9430088N01Rik antibody; ABH8 antibody; alkB alkylation repair homolog 8 (E. coli) antibody; alkB alkylation repair homolog 8 antibody; AlkB homologue 8 antibody; ALKB8_HUMAN antibody; ALKBH8 antibody; Alkylated DNA repair protein alkB homolog 8 antibody; FLJ38204 antibody; MGC10235 antibody; OTTHUMP00000211286 antibody; OTTHUMP00000211287 antibody; Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody; RGD1304687 antibody; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
  • 基因功能參考文獻：
    1. findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer PMID: 27329810
    2. Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. PMID: 21285950
    3. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. PMID: 20123966
    4. Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival. PMID: 20308323
    5. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8. PMID: 19293182

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Widely expressed, with highest expression in spleen, followed by pancreas and lung.
  • 數據庫鏈接：

    HGNC: 25189

    OMIM: 613306

    KEGG: hsa:91801

    STRING: 9606.ENSP00000374219

    UniGene: Hs.503763



主站蜘蛛池模板： 久久香蕉国产线看观看手机| 波多野结衣50连登视频| 色婷婷久久久swag精品| 亚洲处破女av日韩精品波波网| 亚洲日韩一中文字暮av| 国产草草影院ccyycom| 日本一卡二卡不卡视频查询| 在线不卡日本v二区到六区| 私人家庭影院5777| 人妻av中文字幕无码专区| 亚洲成av人片一区二区密柚| 免费人成视频网站在线观看18 | 中文字幕制服丝袜第57页| 欧美饥渴熟妇高潮喷水水| 业余 自由 性别 成熟视频 视频| 国产欧美在线一区二区三 | 久久精品国产99精品亚洲| 男人边吃奶边做好爽免费视频| 性色av蜜臀av色欲av| 亚洲精品久久久久久久蜜臀老牛| 久久精品国产只有精品2020| 天堂资源中文| 人妻 日韩精品 中文字幕| 免费无码黄动漫十八禁| 久久国产高潮流白浆免费观看| 成人无码免费一区二区三区| 久久精品人妻一区二区三区| 国产午夜无码片在线观看影视| 小泽玛利亚一区二区在线观看| 成人做爰www网站视频| 国产公妇仑乱在线观看| 很黄很黄的曰批视频| 少妇被爽到高潮动态图| 亚洲精品无码mv在线观看| 国产三级aⅴ在在线观看| 国产三级在线观看完整版| 国产精品高潮呻吟av久久4虎| 台湾无码av一区二区三区| 特级毛片a片久久久久久| 中文字幕av无码不卡| 久久精品囯产精品亚洲|