在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALKBH8 Antibody

  • 中文名稱:
    ALKBH8兔多克隆抗體
  • 貨號:
    CSB-PA842644ESR2HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALKBH8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALKBH8
  • 別名:
    4930562C03Rik antibody; 8030431D03Rik antibody; 9430088N01Rik antibody; ABH8 antibody; alkB alkylation repair homolog 8 (E. coli) antibody; alkB alkylation repair homolog 8 antibody; AlkB homologue 8 antibody; ALKB8_HUMAN antibody; ALKBH8 antibody; Alkylated DNA repair protein alkB homolog 8 antibody; FLJ38204 antibody; MGC10235 antibody; OTTHUMP00000211286 antibody; OTTHUMP00000211287 antibody; Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody; RGD1304687 antibody; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
  • 基因功能參考文獻:
    1. findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer PMID: 27329810
    2. Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. PMID: 21285950
    3. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. PMID: 20123966
    4. Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival. PMID: 20308323
    5. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8. PMID: 19293182

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    AlkB family
  • 組織特異性:
    Widely expressed, with highest expression in spleen, followed by pancreas and lung.
  • 數據庫鏈接:

    HGNC: 25189

    OMIM: 613306

    KEGG: hsa:91801

    STRING: 9606.ENSP00000374219

    UniGene: Hs.503763



主站蜘蛛池模板: 中文www新版资源在线| 99国产精品久久久久久久成人热| 成 年 人 黄 色 大 片大 全| 无码国内精品人妻少妇| 午夜视频在线在免费| 国产成年无码久久久免费| 亚洲精品欧美二区三区中文字幕| 国产精品成人免费一区久久羞羞 | 18禁无遮挡羞羞污污污污网站| 琪琪午夜伦埋影院77| 人妻夜夜爽天天爽三区丁香花| 久久精品农村毛片| 亚洲一区二区三区无码av| 国产人妻久久精品一区二区三区 | 国产午睡沙发被弄醒完整版| 久久av高潮av无码av喷吹| 国产乡下妇女做爰| av天堂永久资源网亚洲高清| 精品无人区麻豆乱码1区2区 | 久久婷婷五月国产色综合 | 国产精品亚洲二区在线播放| 717影院理论午夜伦八戒| 一 级 黄 色 片免费网站| 内射人妻无套中出无码| 日韩精品亚洲人旧成在线| 日本另类αv欧美另类aⅴ| 日本体内she精高潮| 亚洲精品一品区二品区三区| 伊人中文字幕无码专区| 亚洲人妻av伦理| 强行交换配乱婬bd| 日韩免费无码人妻波多野| 亚洲精品无码久久久| 亚洲欧美精品伊人久久| 国产亚洲精品久久久久9999| 免费国产午夜视频在线| 少妇太爽了在线观看免费视频 | 久久亚洲国产精品成人av秋霞| 专干熟肥老妇人视频在线看| 欧美xxxx做受视频| 亚洲人av高清无码|