在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Adenylate cyclase type 3 (ADCY3) , Partial

In Stock
  • 中文名稱:
    Recombinant Human Adenylate cyclase type 3 (ADCY3) , Partial
  • 貨號:
    CSB-EP001339HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    ATP pyrophosphate-lyase 3;Adenylate cyclase type III;AC-III;Adenylate cyclase, olfactive type;Adenylyl cyclase 3;AC3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    40.2 kDa
  • 表達區域:
    854-1144aa
  • 氨基酸序列
    YYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
  • 基因功能參考文獻:
    1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet. PMID: 29921800
    2. In peripheral organs, AC3 is present mainly in primary cilia in cells of the mesenchymal lineage. In epithelia, the apical cilium of renal and pancreatic tubules and of ductal plate in liver is AC3-negative whereas the cilium of basal cells of stratified epithelia is AC3-positive. Using fibroblasts cell culture, we show that AC3 appears at the plasma membrane of the primary cilium as soon as this organelle develops. PMID: 28122017
    3. Similar results were obtained after sustained stimulation with NKH477 to directly activate adenylyl cyclase PMID: 25431134
    4. The association signal of height-adjusted BMI at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. PMID: 25044758
    5. Data demonstrate that the expression of ADCY3 is regulated through an epigenetic mechanism. PMID: 24113161
    6. endoplasmic reticulum calcium store operated cAMP production occurred preferentially via the adenylate cyclase 3 PMID: 22681560
    7. Genetically mutated serine(1076) of adenylyl cyclase III (ACIII) affects neither the cilial localization nor expression level of ACIII in olfactory sensory neurons. PMID: 23077041
    8. This study suggested that the adenylate cyclase 3 (ADCY3, 2p23.3) related to major depressive disorder. PMID: 21042317
    9. Data show that AC3 genetic polymorphisms are associated with decreased risk of obesity among adults but not in children in a Chinese Han population. PMID: 21079816
    10. identified AC3as the predominant AC isoform in human platelets, the activity of which may affect the extent and duration of the net aggregation response by modulating deaggregation PMID: 12623444
    11. expression of nodular ADCY6, but not ADCY3, was lower than the expression of both in perinodular tissue, which may be part of the mechanisms occurring in the hyperfunctioning nodules PMID: 12782409
    12. Establishment of the mature glomerular array in transgenic mice requires adenylyl cyclase 3, a key component of the odorant receptor-mediated cyclic AMP-dependent signaling cascade. PMID: 17581954
    13. This the first evidence that AC3 polymorphisms confer the risk susceptibility to obesity in Swedish men with and without type 2 diabetes. PMID: 17895882
    14. These results suggest that the length of primary cilia is controlled, at least in part, by the adenylate cyclase III-cAMP signaling pathway. PMID: 19576885

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Cell projection, cilium. Golgi apparatus.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle. Detected in testis.
  • 數據庫鏈接:

    HGNC: 234

    OMIM: 600291

    KEGG: hsa:109

    STRING: 9606.ENSP00000260600

    UniGene: Hs.467898



主站蜘蛛池模板: 亚洲欧洲日产最新| 女人被男人爽到呻吟的视频| 欧美顶级metart裸体全部自慰| 久久精品无码免费不卡 | 亚洲人成网77777色在线播放| 92国产精品午夜免费福利视频| 潮喷失禁大喷水av无码| 午夜成人理论无码电影在线播放| 国产在视频线精品视频| 大桥未久亚洲一区二区| 国产黑色丝袜视频在线观看网红| 伊人久久大香线蕉综合75| 欧美在线 | 亚洲| 日韩国产亚洲欧美中国v| 狠狠色丁香久久婷婷综合_中| 亚洲日韩国产精品第一页一区| 成年无码av片在线| 日本精品中文字幕在线播放| 一本色道久久88精品综合| 国产成人精品三级麻豆| 国产极品美女到高潮| 亚洲区小说区激情区图片区| 国产一卡二卡三卡四卡视频版| 92国产精品午夜福利| 国产一区二区三区 韩国女主播| 国产啪精品视频网站免| 人妻巨大乳hd免费看| 欧美大屁股xxxx高跟欧美黑人| 国产精品一国产精品一k频道 | 国产爆乳无码av在线播放| 国产 | 欧洲野花视频天堂视频p| 无套内射极品少妇chinese| 国产亚洲精品97在线视频一| 亚洲日韩a∨无码久| 永久免费无码av网站在线观看 | 风韵犹存丰满大屁股熟妇视频| 加勒比色综合久久久久久久久| 亚洲熟妇自偷自拍另类| 人妻熟女一区二区aⅴ向井蓝| 欧美 亚洲 国产 制服 中文| 九九九精品成人免费视频小说|